Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

[Neuron] Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.

Feedforward and Feedback Mechanisms Cooperatively Regulate Rapid Experience-Dependent Response Adaptation in a Single Thermosensory Neuron Type

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that rapid thermosensory response adaptation in AFD was mediated via cGMP and calcium-dependent feedforward and feedback mechanisms operating at the level of primary thermotransduction.

Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

[Science Signaling] Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.

Prosaposin Maintains Adult Neural Stem Cells in a State Associated with Deep Quiescence

[Stem Cell Reports] Using RNA sequencing and pharmacological manipulations, investigators showed that lysosomes were necessary for neural stem cell quiescence maintenance.

The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act

[Journal Of Neurophysiology] The author offersseveral suggestions for future research investigating the precise spatiotemporal control of Notch signaling throughout the development of the central nervous system.

Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’s

[Science] A cohort of transgenic marmoset models may help predict neurological conditions and test potential treatments.

Predictive Value of Procollagen C-Protease Enhancer Protein on the Prognosis of Glioma Patients

[Heliyon] Multiple bioinformatics techniques have been employed to investigate the roles of procollagen c-protease enhancer protein (PCOLCE) in glioma, consisting of the correlation between PCOLCE and prognosis, immune checkpoints, immune cell infiltrates, and tumor microenvironment.

Small-Molecule Caspase-1 Inhibitor CZL80 Terminates Refractory Status Epilepticus via Inhibition of Glutamatergic Transmission

[Acta Neuropathologica] The authors highlighted the therapeutic potential of CZL80, a small molecule that inhibits caspase-1, in status epilepticus termination and its related mechanisms.

Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

[Science Translational Medicine] The authors found that PTEN directly interacted with MMS19 and competitively disrupted MMS19-based cytosolic iron-sulfur cluster assembly machinery in differentiated glioma cells.

Microglial Over-Pruning of Synapses During Development in Autism-Associated SCN2A-Deficient Mice and Human Cerebral Organoids

[Molecular Psychiatry] Scientists established a microglia-incorporated human cerebral organoid model carrying an SCN2A protein-truncating mutation identified in children with autism spectrum disorder. They found that human microglia display increased elimination of post-synapse in cerebral organoids carrying the SCN2A mutation.

Mutant Huntingtin Protein Induces MLH1 Degradation, DNA Hyperexcision, and cGAS–STING-Dependent Apoptosis

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators show that huntingtin (HTT) interacted with both exonuclease 1 (Exo1) and MutLα, a negative regulator of Exo1.

$3.3M Investment in Basic Mental Health Research

[Brain Canada Foundation] Three recipients, along with their dedicated research teams, receive $1.1 million each to advance our understanding of mental health conditions at a fundamental level.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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