Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Lineage Specific Transcription Factor Waves Reprogram Neuroblastoma from Self-Renewal to Differentiation

April 24, 2024

[Nature Communications] To identify super-enhancers driving transcription factor regulators, investigators used all-trans retinoic acid to induce neuroblastoma growth arrest and differentiation.

Endogenous Mutant Huntingtin Alters the Corticogenesis via Lowering Golgi Recruiting ARF1 in Cortical Organoid

April 24, 2024

[Molecular Psychiatry] The authors replicated the altered corticogenesis in the Huntington’s disease (HD) fetal brain using HD patient-derived human cortical organoids.

Aspen Neuroscience Announces First Patient Dosed in First-in-Human Phase I/IIa Clinical Trial of Autologous Neuronal Cell Replacement Therapy for Parkinson’s Disease

April 24, 2024

[Aspen Neuroscience] Aspen Neuroscience, Inc. announced that the first patient has been dosed in the ASPIRO trial, a Phase I/IIa open label clinical trial to assess safety and tolerability of ANPD001.

New Research Suggests Cerebellum May Play Important Role in Autism

April 24, 2024

[UC Davis Health] Researchers in the UC Davis College of Biological Sciences have received a grant to study the role of the cerebellum in autism.

Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons

April 22, 2024

[Small] Microfluidics and two-photon confocal microscopy was applied to screen nanocarriers for transport efficacy and gain mechanistic insights into their interactions with neurons.

Reversal of C9orf72 Mutation-Induced Transcriptional Dysregulation and Pathology in Cultured Human Neurons by Allele-Specific Excision

April 17, 2024

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators generated five different genomic excisions at the C9orf72 locus in a patient-derived iPSC line and a non-diseased wild-type line, and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/ALS in motor neurons differentiated from these lines.

Nose-to-Brain Selective Drug Delivery to Glioma via Ferritin-Based Nanovectors Reduces Tumor Growth and Improves Survival Rate

April 17, 2024

[Cell Death & Disease] The authors demonstrated that a nanocarrier, named The-0504, could cross the blood-brain barrier and specifically deliver the payload to gliomas that express high amounts of the ferritin/transferrin receptor TfR1 (CD71).

The Autism Susceptibility Kinase, TAOK2, Phosphorylates eEF2 and Modulates Translation

April 17, 2024

[Science Advances] Scientists used proteomics, genetics, and translation assays in cultured cells and mouse brains to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models.

Rebound Growth of BRAF Mutant Pediatric Glioma Cells after MAPKi Withdrawal is Associated with MAPK Reactivation and Secretion of Microglia-Recruiting Cytokines

April 17, 2024

[Journal Of Neuro-Oncology] Four patient-derived pediatric glioma models were investigated to model rebound growth in vitro based on viable cell counts in response to mitogen-activated protein kinase (MAPK) inhibitor (MAPKi) treatment and withdrawal.

An Improved Method for Generating Human Spinal Cord Neural Stem Cells

April 17, 2024

[Experimental Neurology] Scientists reported further optimization of methods for deriving and sustaining cultures of human spinal cord neural stem cell lines that resulted in improved karyotypic stability while retaining anatomical efficacy in vivo.

Microglial P2Y6 Calcium Signaling Promotes Phagocytosis and Shapes Neuroimmune Responses in Epileptogenesis

April 16, 2024

[Neuron] Researchers demonstrated that P2Y6 signaling impacted multiple aspects of myeloid cell immune function during epileptogenesis.

GUCY2C Signaling Limits Dopaminergic Neuron Vulnerability to Toxic Insults

April 16, 2024

[npj Parkinson's Disease] Scientists uncovered a previously unexpected role for the guanylyl cyclase C (GUCY2C)-cyclic guanosine monophosphate signaling axis in controlling mitochondrial dysfunction and toxicity in substantia nigra pars compacta dopaminergic neurons.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.