Volume 14.24 | Jun 24

Neural Cell News 14.24 | June 24 2020
Neural Cell News by STEMCELL Technologies
Vol. 14.24 – 24 June, 2020
TOP STORY

Reversing a Model of Parkinson’s Disease with In Situ Converted Nigral Neurons

Investigators report an efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB.
[Nature]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

Scientists showed in xenograft models that targeting diacylglycerol-acyltransferase 1 blocked lipid droplet formation, induced tumor cell apoptosis, and markedly suppressed glioblastoma growth.
[Cell Metabolism]

Abstract

The Stem Cell Marker Prom1 Promotes Axon Regeneration by Down-Regulating Cholesterol Synthesis via Smad Signaling

Elevating prominin-1 levels in cultured dorsal root ganglion neurons or in mice via adeno-associated virus-mediated gene delivery enhanced axon regeneration in vitro and in vivo, allowing outgrowth on an inhibitory substrate.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

Nolz1 Expression Is Required in Dopaminergic Axon Guidance and Striatal Innervation

Investigators demonstrated a striatal-specific requirement of transcriptional regulator Nolz1 in establishing dopaminergic circuitry formation.
[Nature Communications]

Full Article

Distinct Synchronization, Cortical Coupling and Behavioral Function of Two Basal Forebrain Cholinergic Neuron Types

Researchers recorded basal forebrain cholinergic neurons in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties.
[Nature Neuroscience]

Abstract

Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch

Scientists introduced an integration-coupled On genetic switch, iOn, which triggered gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.
[Neuron]

Full ArticleGraphical Abstract

Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury

Transplanted skin-derived precursors differentiated into Schwann cells (SCs) filled much of the lesion sites and greatly enhanced the presence of endogenous SCs, which myelinated thousands of sprouting/spared host axons in and around the injury site.
[Stem Cell Reports]

Full Article

In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment

Scientists generated human iPSC-derived neurons exhibiting spontaneous oscillatory activity after cultivation of up to six months, which resembled early oscillations observed in rodent neurons. This behavior was found in neurons generated using a more “native” embryoid body protocol, in contrast to a “fast” protocol based on neurogenin 2 overexpression.
[Stem Cell Reports]

Full ArticleGraphical Abstract

Lysosomal Perturbations in Human Dopaminergic Neurons Derived from Induced Pluripotent Stem Cells with PARK2 Mutation

PARK2 knockout neurons exhibited a perturbed lysosomal morphology with enlarged electron-lucent lysosomes and an increased lysosomal content, which was exacerbated by mitochondrial stress and could be ameliorated by antioxidant treatment.
[Scientific Reports]

Full Article

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REVIEWS

Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

The authors present an overview of recent studies on the developmental origins, migratory properties, and morphology of chandelier cells.
[Trends in Neurosciences]

Abstract

INDUSTRY AND POLICY NEWS

University of Kentucky, Children’s Hospital of Philadelphia and Mitochon Pharmaceuticals Awarded NIH Grant for Traumatic Brain Injury Studies

Mitochon Pharmaceuticals announced that they, in partnership with the University of Kentucky and Children’s Hospital of Philadelphia, were awarded a $3.2M National Institutes of Health grant to study Mitochon’s mitochondrial targeted drug therapies for treating traumatic brain injury.
[Mitochon Pharmaceuticals]

Press Release

COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]

Editorial

FEATURED EVENT

Glia in Health and Disease

2020-07-16 – 2020-07-16
Virtual

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JOB OPPORTUNITIES

Assistant Professor – Pluripotent Stem Cell Biology

Sup’Biotech Engineering School – Villejuif, Lyon, France

Scientific Leader – Neuroscience and Technology Translation

Simon Fraser University – Burnaby, British Columbia, Canada

Postdoctoral Position – Brain Models for Neurodegenerative Diseases

F. Hoffmann-La Roche AG – Basel, Switzerland

Tenure-Track Investigator – Computational Neuroscientist

NIH National Institute of Mental Health – Bethesda, Maryland, United States

Postdoctoral Fellow – Genes in Neural Circuits

Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

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