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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Microglial P2Y6 Calcium Signaling Promotes Phagocytosis and Shapes Neuroimmune Responses in Epileptogenesis
[Neuron] Researchers demonstrated that P2Y6 signaling impacted multiple aspects of myeloid cell immune function during epileptogenesis.
GUCY2C Signaling Limits Dopaminergic Neuron Vulnerability to Toxic Insults
[npj Parkinson's Disease] Scientists uncovered a previously unexpected role for the guanylyl cyclase C (GUCY2C)-cyclic guanosine monophosphate signaling axis in controlling mitochondrial dysfunction and toxicity in substantia nigra pars compacta dopaminergic neurons.
NF1 Mutation-Driven Neuronal Hyperexcitability Sets a Threshold for Tumorigenesis and Therapeutic Targeting of Murine Optic Glioma
[Neuro-Oncology] Using mouse models of neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG), the authors demonstrated that Nf1 mutation induced neuronal hyperexcitability and midkine expression, which activated an immune axis to support tumor growth, such that high-dose lamotrigine treatment reduced Nf1-OPG proliferation.
Neurofilaments as Biomarkers in Neurological Disorders — towards Clinical Application
[Nature Reviews Neurology] The authors summarize potential clinical applications of neurofilaments as a biomarker of neuro-axonal damage in a range of neurological disorders, including MS, Alzheimer's disease, frontotemporal dementia, ALS, traumatic brain injury, and Parkinson's disease.
AviadoBio Announces First Patient Treated in ASPIRE-FTD Clinical Trial Evaluating AVB-101 for Frontotemporal Dementia with GRN Mutations
[AviadoBio] AviadoBio announced that the first patient has been treated in the Phase I/II ASPIRE-FTD trial evaluating AviadoBio’s investigational gene therapy, AVB-101, in people with frontotemporal dementia with progranulin gene mutations.
Therapeutic Role of PTEN in Tissue Regeneration for Management of Neurological Disorders: Stem Cell Behaviors to an In-Depth Review
[Cell Death & Disease] The authors provide a comprehensive overview of the mechanisms by which phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates activities of different stem cell populations and influences neurological disorders, encompassing autism, stroke, spinal cord injury, traumatic brain injury, Alzheimer’s disease, and Parkinson’s disease.
Glutamatergic Neuronal Activity Regulates Angiogenesis and Blood-Retinal Barrier Maturation via Norrin/β-Catenin Signaling
[Neuron] Using in vivo genetic studies in mice, scRNA-seq, and functional validation, researchers showed that deep plexus angiogenesis and paracellular blood-retinal barrier maturation were delayed in Vglut1−/− retinas where neurons failed to release glutamate.
Insights for Disease Modeling from Single-Cell Transcriptomics of iPSC-Derived Ngn2-Induced Neurons and Astrocytes across Differentiation Time and Co-Culture
[BMC Biology] Scientists examined the homogeneity and similarity of human-induced pluripotent stem cells (hiPSC) derived neuron (hiPSC-N) and hiPSC derived astrocyte A (hiPSC-A) to their in vivo counterparts, the impact of different lengths of time post Ngn2 induction on hiPSC-N (15 or 21 days), and the impact of hiPSC-N/hiPSC-A co-culture.
Rare Genetic Variation in Fibronectin 1 (FN1) Protects against APOEε4 in Alzheimer’s Disease
[Acta Neuropathologica] Researchers hypothesized that APOEε4 carriers without dementia might carry genetic variations that could protect them from developing APOEε4-mediated Alzheimer's Disease pathology.
Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons
[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.
Microtubule Polarity Determines the Lineage of Embryonic Neural Precursor in Zebrafish Spinal Cord
[Communications Biology] Investigators found two distinct pools of neural precursors based on Sara endosome inheritance and spindle-microtubule enrichment. Symmetric or asymmetric levels of spindle-microtubules drive differently Sara endosomes inheritance and predict neural precursor lineage.
Essential Pharma Acquires Renaissance Pharma Ltd with Its Clinical Stage Immunotherapy for the Treatment of High-Risk Neuroblastoma
[Essential Pharma] Essential Pharma announced that it has completed the acquisition of the entire issued share capital of Renaissance Pharma Ltd. Renaissance Pharma is a clinical stage pharmaceutical company focused on the development of life changing therapies in pediatric rare disease.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
