Scientists Discover Method for Targeting the ‘Achilles Heel’ of Neuroblastoma
Scientists have identified a critical molecular ‘feedback loop’ that accelerates the progression of neuroblastoma, a cancer of the nervous system in children that is triggered in embryonal nerve cells. [Press release from University of New South Wales discussing online prepublication in Science Translational Medicine] Press
Release|Abstract
Aneuploidy Causes Premature Differentiation of Neural and Intestinal Stem Cells
Scientists showed that aneuploidy causes brain size reduction due to a decrease in the number of proliferative neural stem cells (NSCs), but not through apoptosis. Instead, aneuploid NSCs present an extended G1 phase, which leads to cell cycle exit and premature differentiation. [Nat Commun] Full Article|Video
Aging Neural Progenitors Lose Competence to Respond to Mitogenic Notch Signaling
The authors found that aging intermediate neural progenitors (INPs) lose competence to respond to constitutively active Notch signaling. They showed that reducing the levels of the old INP temporal transcription factor Eyeless/Pax6 allows Notch signaling to promote the de-differentiation of INP progeny into ectopic INPs, thereby creating a proliferative mass of ectopic progenitors in the brain. [Curr Biol] Abstract
Visit our reviews page to see a complete list of reviews in the neural cell research field.
INDUSTRY NEWS
UCLA Scientists Receive Prestigious BRAIN Initiative Grant from NIH
Five UCLA scientists have received a grant from the National Institutes of Health for a study that could provide a better understanding of how neural circuits in the brain process, encode, store and retrieve information. The three-year, $2.3 million grant will support the team’s work to develop methods for recording the activity of intact neural networks in living animals. [University of California Los Angeles (UCLA)] Press Release
Van Andel Research Institute Expands into New Areas of Parkinson’s Research
Van Andel Research Institute is continuing the expansion of its neurodegenerative disease research program, which aims to answer fundamental questions about diseases such as Parkinson’s and Alzheimer’s, with the addition of two outstanding scientists. Gerhard Coetzee, Ph.D., and Viviane Labrie, Ph.D., will join the Center for Neurodegenerative Science. [Van Andel Research Institute] Press Release
Recruit Top Talent:
Reach more than 60,000 potential candidates by posting
your organization’s career opportunities on the Connexon Creative Job Board at no cost.
Have we missed an important article or publication in Neural Cell News? Click here to submit!
