Targeting Mutant Proteins Might Be Silver Bullet for Neurodegenerative Diseases
Scientists used a range of neuro-genetic, gene therapy, biochemical and structural biology research techniques to discover that the mutant GlyRS enzyme blocked molecular signals important for maintaining the health of motor neurons, the cells that carry messages from the brain to the muscles of the extremities. [Press release from Salk Institute for Biological Studies discussing online prepublication in Nature] Press Release|Abstract
Generation of Functional Human Serotonergic Neurons from Fibroblasts
Scientists identified and overexpressed key transcription factors to successfully generate human serotonergic neurons. They found that overexpressing the transcription factors NKX2.2, FEV, GATA2 and LMX1B in combination with ASCL1 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts. [Mol Psychiatry] Abstract
NEDD4-Mediated HSF1 Degradation Underlies α-Synucleinopathy
Researchers discovered aberrant heat shock transcription factor 1 (HSF1) degradation by aggregated α-synuclein (or α-synuclein-induced proteotoxic stress) in transfected neuroblastoma cells. HSF1 dysregulation via α-synuclein was confirmed by in vivo assessment of mouse and in situ studies of human specimens with α-synucleinopathy. [Hum Mol Genet] Abstract|Full Article
Effects of Melatonin and Its Analogues on Neural Stem Cells
The authors summarize the beneficial effects of melatonin on neural stem cells and discuss the potential usage of melatonin and its derivatives or analogues in the treatment of central nervous system neurodegenerative diseases. [Mol Cell Endocrinol] Abstract
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