The Unfolded Protein Response in Neurodegenerative Diseases: A Neuropathological Perspective|
The authors address the importance of investigation of human brain material for the interpretation of the role of the unfolded protein response (UPR) in neurological diseases. They discuss evidence for UPR activation in neurodegenerative diseases, and the methodology to study UPR activation and its connection to brain pathology is addressed. [Acta Neuropathol] Full Article
TRPM7 and Its Role in Neurodegenerative Diseases
The authors focus on the emerging role of transient potential melastatin-7 (TRPM7) channel in not only regulating Ca2+ and Mg2+ homeostasis necessary for biological functions, but also how alterations in TRPM7 function/expression could induce neurodegeneration. [Channels] Abstract
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