Volume 9.22 | Jun 10

Neural Cell News 9.22 June 10, 2015
Neural Cell News
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Cdk1 Activates Pre-Mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells
Investigators found that Cdk1 serves as a direct master controller for nuclear envelope dynein recruitment in neural stem cells and HeLa cells. [Dev Cell] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells
Markers of cellular proliferation and differentiation, mitochondrial health, cell death/damage, and oxidative damage were monitored to determine the effects of ketamine on neural stem cell proliferation and neural stem cell differentiation. [Mol Neurobiol] Abstract

Microglia-Derived IL-1β Triggers p53-Mediated Cell Cycle Arrest and Apoptosis in Neural Precursor Cells
Scientists investigated the mechanisms by which microglia affect neural precursor cell (NPC) proliferation and survival. Importantly, they demonstrated that interleukin-1β (IL-1β) produced by lipopolysaccharide/interferon-γ-activated microglia is necessary to induce cell cycle arrest and apoptosis in NPCs in vitro. [Cell Death Dis] Full Article

Inhibition of Hypoxia Inducible Factors Combined with All-Trans Retinoic Acid Treatment Enhances Glial Transdifferentiation of Neuroblastoma Cells
In neuroblastoma cell lines, the combination of all-trans retinoic acid with HIF1A or EPAS1 silencing led to an acquired glial-cell phenotype and enhanced expression of glial-cell differentiation markers. [Sci Rep] Full Article

Co-Existence of Intact Stemness and Priming of Neural Differentiation Programs in mES Cells Lacking Trim71
Investigators demonstrated that Tripartite motif (Trim)71 is not involved in regulatory networks of pluripotency but regulates neural differentiation. Loss of Trim71 in murine embryonic stem (mES) cells leaves stemness and self-maintenance of these cells intact, but many genes required for neural development are up-regulated at the same time. [Sci Rep] Full Article

Ionizing Radiation Perturbs Cell Cycle Progression of Neural Precursors in the Subventricular Zone without Affecting Their Long-Term Self-Renewal
Subventricular zone neural stem/progenitor cells isolated from newborn mouse pups were analyzed for proliferation, self-renewal, and differentiation, shortly after irradiation. [ASN Neuro] Full Article

Viability and Neuronal Differentiation of Neural Stem Cells Encapsulated in Silk Fibroin Hydrogel Functionalized with an IKVAV Peptide
Both unmodified and modified silk fibroin hydrogels were obtained, through sonication, with mechanical stiffness comparable to that of brain tissue. Human neural stem cells were encapsulated in both hydrogels and the effects of IKVAV peptide conjugation on cell viability and neural differentiation were assessed. [J Tissue Eng Regen Med] Abstract

Effect of Testosterone on Neuronal Morphology and Neuritic Growth of Fetal Lamb Hypothalamus-Preoptic Area and Cerebral Cortex in Primary Culture
Cells derived from the hypothalamus-preoptic area and cerebral cortex of lamb fetuses were grown in primary culture to examine the direct morphological effects of testosterone on these cellular components. [PLoS One] Full Article

Dual Polarization of Microglia Isolated from Mixed Glial Cell Cultures
Researchers compared the immunological states between microglia isolated by mixed glial culture system (MGCS) and microglia isolated by magnetic activated cell sorting (MACS). They showed that microglia isolated by MGCS exhibit a stronger immune-activated state than microglia isolated by MACS. [J Neurosci Res] Abstract

Conversion of Adipose Tissue-Derived Mesenchymal Stem Cells to Neural Stem Cell-Like Cells by a Single Transcription Factor, Sox2
When the authors introduced the Sox2 gene into adipose tissue–derived mesenchymal stem cells by retrovirus, they exhibited a typical neural stem cell (NSC)-like morphology, and could be passaged continuously, and expressed NSC specific markers Sox2 and Pax6. [Cell Reprogram] Abstract

Open Access JoVE Protocol: Discriminating NSCs from NPCs with the NeuroCult™ NCFC Assay
Single-Molecule Insights into mRNA Dynamics in Neurons
The authors discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. [Trends Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.
Novel Cellular Therapeutic Approach for ALS Gets FDA Clearance for First-in-Human Trials
Q Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application for the initiation of Phase I/IIa clinical trials of its Q-Cells® product in patients with amyotrophic lateral sclerosis (ALS). [Q Therapeutics, Inc.] Press Release

StemCells, Inc. Announces Commencement of the Second Cohort of the Pathway™ Study in Cervical Spinal Cord Injury
StemCells, Inc. announced that it has enrolled its first subject in Cohort 2 of its Phase II Pathway Study. The study is designed to assess the efficacy of the company’s proprietary HuCNS-SC® platform technology (purified human neural stem cells) for the treatment of cervical spinal cord injury. [StemCells, Inc.] Press Release

FDA Grants IND Approval for Phase IIa Clinical Trial Using Stemedica’s itMSC Therapy to Treat Alzheimer’s Disease
Stemedica Cell Technologies, Inc. received the FDA’s investigational new drug (IND) approval for a United States-based, Phase IIa clinical study using its allogeneic stem-cell therapy to treat subjects with mild to moderate dementia due to Alzheimer’s disease. [Stemedica Cell Technologies, Inc.] Press Release

Asterias Biotherapeutics Announces First Patient Treated in Phase I/IIa Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury
Asterias Biotherapeutics, Inc. announced that the first patient was successfully dosed in a Phase I/IIa clinical trial evaluating activity of escalating doses of AST-OPC1 in newly injured patients with sensory and motor complete cervical spinal cord injury. [Asterias Biotherapeutics, Inc.] Press Release

Blaze Bioscience Announces Open Enrollment for Phase I Clinical Trial of Tumor Paint BLZ-100 in Children with Brain Cancer
Blaze Bioscience announced open enrollment for the first clinical study of Tumor Paint BLZ-100 in children with brain cancer. The study, entitled “A Phase I dose-escalation and expansion study of BLZ-100 in pediatric subjects with primary central nervous system tumors,” will be conducted at Seattle Children’s Hospital. [Blaze Bioscience] Press Release

STEMCELL Technologies Named Company of the Year by BIOTECanada
STEMCELL Technologies Inc. will be presented with the Biotech Company of the Year award by BIOTECanada at this year’s BIO International Convention in Philadelphia. [STEMCELL Technologies Inc. (Business Wire)] Press Release

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NEW 2015 Midwest Conference on Cell Therapy & Regenerative Medicine
September 18-19, 2015
Kansas City, United States

Visit our events page to see a complete list of events in the neural cell community.
NEW Postdoctoral Fellow – Neural Stem Cells (Children’s Hospital of Philadelphia)

NEW Postdoctoral Associate – Neuro-Oncology (University of Florida)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Neuroplacentology (Children’s National Medical Center)

Postdoctoral Fellow Positions – iPSC Research and Banking (University of Magna Graecia)

Postdoctoral Fellow – Stem Cell Biology/Neuroscience (Tulane University)

Postdoctoral Fellowships – Neurodevelopment (Vollum Institute)

Faculty Positions (IDG/McGovern Institute for Brain Research at Peking University)

PhD Studentship – Neurobiology (Istituto Italiano di Tecnologia)

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