Cancer Genes Turned Off in Deadly Brain Cancer
Scientists identified a small RNA molecule called miR-182 that can suppress cancer-causing genes in mice with glioblastoma multiforme, a deadly and incurable type of brain tumor. [Press release from Northwestern University discussing online prepublication in Genes and Development] Press Release|Abstract
Alzheimer’s Disease-Related Amyloid-β Induces Synaptotoxicity in Human iPS Cell-Derived Neurons
Scientists established highly reproducible, human induced pluripotent stem cell-derived cortical cultures as a cellular model to study the synaptotoxic effects of amyloid-β. They developed a highly efficient immunopurification procedure yielding immature neurons that express markers of deep layer cortical pyramidal neurons and GABAergic interneurons. [Cell Death Dis] Full Article
Deubiquitinating Enzymes Regulate Hes1 Stability and Neuronal Differentiation
Knockdown of ubiquitin-specific protease 22 shortened the half-life of hairy and enhancer of split 1 (Hes1), delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas miss-expression of ubiquitin-specific protease 27x reduced neuronal differentiation. [FEBS J] Abstract|Full Article
SOX7 Interferes with β-Catenin Activity to Promote Neuronal Apoptosis
The authors investigated the expression pattern and role of SOX7 in potassium deprivation-induced neuronal apoptosis. They showed that both mRNA and protein levels of SOX7 were up-regulated when potassium was deprived. [Eur J Neurosci] Abstract
Disturbed Calcium Signaling in Spinocerebellar Ataxias and Alzheimer’s Disease
Neurodegenerative disorders, such as spinocerebellar ataxias and Alzheimer’s disease represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. [Semin Cell Dev Biol] Abstract
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INDUSTRY NEWS
$10 Million Gift Establishes Center to Develop Personalized Medicine to Fight Cancer
A $10 million gift from entrepreneurs Emmet and Toni Stephenson and their daughter Tessa Stephenson Brand will further the pioneering efforts of Keck Medicine of the University of Southern California (USC) Professor David B. Agus, MD, to change the way cancer is viewed and treated and forge a path to personalized medicine. [Keck Medicine of USC] Press Release
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