Scientists Get One Step Closer to Finding How to Repair Damaged Nerve Cells
Scientists uncovered a new kind of synergy in the development of the nervous system, which explains an important mechanism required for neural circuits to form properly. Their breakthrough could eventually help develop tools to repair nerve cells following injuries to the nervous system. [Press release from IRCM discussing online publication in PLoS Biology] Press Release|Full Article
Slowly Dividing Neural Progenitors Are an Embryonic Origin of Adult Neural Stem Cells
Analysis of cell cycle progression by examining retention of a histone 2B-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day 13.5 and E15.5 while other embryonic NPCs continue to divide rapidly. [Nat Neurosci] Abstract
CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4
Scientists derived neural progenitor cell (NPC) cultures from Cxcr4 KO mice and used transwell and stripe assays to determine the cell migration. NPCs derived from Cxcr4 KO mice polarized and migrated in response to CXCL12 gradient, suggesting that CXCR7 could serve as an independent migration receptor. [Stem Cells] Abstract
Glioblastoma: Molecular Pathways, Stem Cells and Therapeutic Targets
Inclusion of novel therapies, such as immuno- and DNA-based therapy, may provide better means of treating glioblastoma (GBM). Furthermore, manipulation of recently discovered non-coding microRNAs, some of which regulate tumor growth through the development and maintenance of GBM stem cells, could provide new prospective therapies. [Cancers] Abstract|Download Full Article
Nanoparticle-Mediated Growth Factor Delivery Systems: A New Way to Treat Alzheimer’s Disease
The authors provide information about the latest advances in the development of growth factor (GF) delivery systems targeting the brain in terms of in vitro and in vivo effects in the context of Alzheimer’s disease and discusses new strategies designed to increase the availability and the specificity of GFs to the brain. [J Control Release] Abstract
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INDUSTRY NEWS
UC Researchers Awarded Stem Cell Grants
University of California (UC) researchers from two campuses received three grants totaling more than $12 million in funding from the state’s stem cell agency to develop stem cell treatments for Huntington’s disease, spina bifida and chronic diabetic wounds. [UC Health] Press Release
Northwestern Medicine Launches Huntington’s Disease Center
Northwestern Medicine® recently launched a multidisciplinary center dedicated to the comprehensive treatment of patients battling Huntington’s disease. The new center will focus on both patient care and research of the inherited disease that causes the progressive breakdown of nerve cells in the brain. [Northwestern Medicine® (PR Newswire Association LLC)] Press Release
$6 Million Gift Will Propel Research at Alzheimer’s Center
With a $6 million investment from the Ellison Foundation, the Alzheimer’s Disease Research Center at the University of Washington will begin a project unique in the United States, one that could revolutionize care for Alzheimer’s. [University of Washington] Article
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