Volume 9.12 | Apr 1

Neural Cell News 9.12 April 1, 2015
Neural Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Scientists Get One Step Closer to Finding How to Repair Damaged Nerve Cells
Scientists uncovered a new kind of synergy in the development of the nervous system, which explains an important mechanism required for neural circuits to form properly. Their breakthrough could eventually help develop tools to repair nerve cells following injuries to the nervous system. [Press release from IRCM discussing online publication in PLoS Biology] Press Release | Full Article
Happy Neurons lead to Happy Neuroscientists: NeuroCult SM Primary Neuronal Culture Kits
 
PUBLICATIONS (Ranked by impact factor of the journal)
Slowly Dividing Neural Progenitors Are an Embryonic Origin of Adult Neural Stem Cells
Analysis of cell cycle progression by examining retention of a histone 2B-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day 13.5 and E15.5 while other embryonic NPCs continue to divide rapidly. [Nat Neurosci] Abstract

SOX2 Primes the Epigenetic Landscape in Neural Precursors Enabling Proper Gene Activation during Hippocampal Neurogenesis
Researchers report a novel function for the pluripotency factor sex-determining region Y-related HMG box 2 (SOX2) in regulating the epigenetic landscape of poised genes activated at the onset of neuronal differentiation. [Proc Natl Acad Sci USA] Abstract

CD133 and DNA-PK Regulate MDR1 via the PI3K- or Akt-NF-κB Pathway in Multidrug-Resistant Glioblastoma Cells In Vitro
Multidrug resistance (MDR) glioblastoma cell lines were created in response to prolonged doxorubicin chemotherapy. CD133, DNA-dependent protein kinase (DNA-PK) and MDR protein 1 (MDR1) were markedly elevated in these cells. CD133 and DNA-PK may increase MDR1 via the phosphatidylinositol-3-kinase (PI3K)-Akt signal pathway. [Oncogene] Abstract

CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4
Scientists derived neural progenitor cell (NPC) cultures from Cxcr4 KO mice and used transwell and stripe assays to determine the cell migration. NPCs derived from Cxcr4 KO mice polarized and migrated in response to CXCL12 gradient, suggesting that CXCR7 could serve as an independent migration receptor. [Stem Cells] Abstract

IGF-1 Signaling Plays an Important Role in the Formation of Three Dimensional Laminated Neural Retina and Other Ocular Structures from Human Embryonic Stem Cells
Researchers report that insulin-like growth factor 1 (IGF-1) can orchestrate the formation of three dimensional ocular-like structures from human embryonic stem cells which, in addition to retinal pigmented epithelium and neural retina, also contain primitive lens and corneal-like structures. [Stem Cells] Abstract

Pig Induced Pluripotent Stem Cell Derived Neural Rosettes Developmentally Mimic Human Pluripotent Stem Cell Neural Differentiation
Researchers report that pig induced pluripotent stem cells (iPSC) can recapitulate events in early mammalian neural development. Pig iPSC line (POU5F1high/SSEA4low) had a higher potential to form neural rosettes containing neuroepithelial cells than either POU5F1low/SSEA4low or POU5F1low/SSEA4high lines. [Stem Cells Dev] Abstract

Development of Circadian Oscillators in Neurosphere Cultures during Adult Neurogenesis
To evaluate circadian timing abilities of cells undergoing neural differentiation, neurospheres were prepared from the mouse subventricular zone, a rich source of adult neural stem cells. [PLoS One] Full Article

Heparin-Binding EGF-Like Growth Factor and Enteric Neural Stem Cell Transplantation in the Prevention of Experimental Necrotizing Enterocolitis in Mice
Scientists determined whether enteric neural stem cell (NSC) transplantation, in conjunction with heparin binding-epidermal growth factor-like growth factor (HB-EGF), could protect against experimental necrotizing enterocolitis. In vitro, HB-EGF effect on NSC proliferation and migration, and the receptors utilized by HB-EGF to exert these effects, were determined. [Ped Res] Abstract

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REVIEWS
Glioblastoma: Molecular Pathways, Stem Cells and Therapeutic Targets
Inclusion of novel therapies, such as immuno- and DNA-based therapy, may provide better means of treating glioblastoma (GBM). Furthermore, manipulation of recently discovered non-coding microRNAs, some of which regulate tumor growth through the development and maintenance of GBM stem cells, could provide new prospective therapies. [Cancers] Abstract | Download Full Article

Nanoparticle-Mediated Growth Factor Delivery Systems: A New Way to Treat Alzheimer’s Disease
The authors provide information about the latest advances in the development of growth factor (GF) delivery systems targeting the brain in terms of in vitro and in vivo effects in the context of Alzheimer’s disease and discusses new strategies designed to increase the availability and the specificity of GFs to the brain. [J Control Release] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.
 
INDUSTRY NEWS
UC Researchers Awarded Stem Cell Grants
University of California (UC) researchers from two campuses received three grants totaling more than $12 million in funding from the state’s stem cell agency to develop stem cell treatments for Huntington’s disease, spina bifida and chronic diabetic wounds. [UC Health] Press Release

Northwestern Medicine Launches Huntington’s Disease Center
Northwestern Medicine® recently launched a multidisciplinary center dedicated to the comprehensive treatment of patients battling Huntington’s disease. The new center will focus on both patient care and research of the inherited disease that causes the progressive breakdown of nerve cells in the brain. [Northwestern Medicine® (PR Newswire Association LLC)] Press Release

$6 Million Gift Will Propel Research at Alzheimer’s Center
With a $6 million investment from the Ellison Foundation, the Alzheimer’s Disease Research Center at the University of Washington will begin a project unique in the United States, one that could revolutionize care for Alzheimer’s. [University of Washington] Article

Accellta Grants Exclusive Rights for Micro-Carrier Free Stem Cells Suspension Culture to STEMCELL Technologies
The stem cell company Accellta announced that it has granted exclusive worldwide rights to STEMCELL Technologies Inc. for manufacturing and distribution of medium for culturing pluripotent stem cells in suspension under feeder-free, non-adherent conditions. [Accellta Ltd.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 21st ISCT Annual Meeting
May 27-30, 2015
Las Vegas, United States

Visit our events page to see a complete list of events in the neural cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellowships – Neuroscience, Physiology, Aging, Neural Systems and Molecular Biology (Baylor College of Medicine)

NEW Postdoctoral Positions – Stem Cell Biology (University of Wisconsin – Madison)

NEW Postdoctoral Fellow – Development of the Nervous System and the Origin of Neural Diversity (Columbia University Medical Center)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Neuroscience (University of Oslo)

PhD Position – Early Human Brain Development Modeling with hiPSCs (University of Bonn)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Assistant Professor – Neuroscience (Georgia State University)

Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Researcher – Epigenetic Mechanisms and Behavioral Outcomes of Developmental Neurotoxicity (Thomas Jefferson University)


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