Volume 9.00 | Jan 7

Newsletter Issue
Neural Cell News 9.00 January 7, 2015
Neural Cell News
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Animal Study Points to a Treatment for Huntington’s Disease
By adjusting the levels of a key signaling protein, researchers improved motor function and brain abnormalities in experimental animals with a form of Huntington’s disease. [Press release from The Children’s Hospital of Philadelphia discussing online prepublication in Neuron] Press Release | Abstract
Webinar: Brent Reynolds on Identification and Characterization of Neural Stem Cells
PUBLICATIONS (Ranked by impact factor of the journal)
Marinesco-Sjögren Syndrome Protein SIL1 Regulates Motor Neuron Subtype-Selective ER Stress in ALS
Scientists show that the molecular environment of the endoplasmic reticulum (ER) between motor neuron subtypes is distinct, with characteristic signatures. They identified cochaperone SIL1, mutated in Marinesco-Sjögren syndrome, as being robustly expressed in disease-resistant slow motor neurons but not in ER stress-prone fast-fatigable motor neurons. [Nat Neurosci] Abstract

Targeting ATM Ameliorates Mutant Huntingtin Toxicity in Cell and Animal Models of Huntington’s Disease
Researchers show that ataxia-telangiectasia mutated (ATM) signaling was consistently elevated in cells derived from Huntington’s disease (HD) mice and in brain tissue from HD mice and patients. ATM knockdown protected from toxicities induced by mutant Huntingtin fragments in mammalian cells and in transgenic Drosophila models. [Sci Transl Med] Abstract

Differential Effects of Extracellular Vesicles Secreted by Mesenchymal Stem Cells from Different Sources on Glioblastoma Cells
Given the ability of mesenchymal stem cells (MSCs) to affect glioma growth, researchers investigated the effects of extracellular vesicles derived from MSCs on U87MG glioblastoma cells line. [Expert Opin Biol Ther] Abstract

Human Cytomegalovirus Gene Expression in Long-Term Infected Glioma Stem Cells
Researchers hypothesized that a specific human cytomegalovirus (HCMV) gene signature may be associated with glioblastoma pathogenesis. They used glioma cell lines and primary glioma stem-like cells infected with clinical and laboratory HCMV strains and measured relative viral gene expression levels along several time points up to 15 weeks post-infection. [PLoS One] Full Article

The Neuron Regrowth Is Associated with the Proliferation of Neural Precursor Cells after Leukemia Inhibitory Factor Administration following Spinal Cord Injury in Mice
Investigators explored whether LIF could promote the proliferation of neural precursor cells (NPCs) and analyzed the correlation between increased NPCs and FluoroGold labeled neurons in mice after spinal cord injury. [PLoS One] Full Article

Electrospun Biomaterial Scaffolds with Varied Topographies for Neuronal Differentiation of Human-Induced Pluripotent Stem Cells
Researchers investigated the effect of micro and nanoscale scaffold topography on promoting neuronal differentiation of human induced pluripotent stem cells and directing the resulting neuronal outgrowth in an organized manner. [J Biomed Mater Res A] Abstract

Identification of a Novel Cell-Penetrating Peptide Targeting Human Glioblastoma Cell Lines as a Cancer-Homing Transporter
Scientists attempted to identify novel cancer-homing cell-penetrating peptides to target glioblastoma multiforme, which is often refractory and resistant to treatment. One of the candidate peptides showed selective cell-penetrating activity in U87MG cells. [Biochem Biophys Res Commun] Abstract

Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia
To understand how haploinsufficiency of progranulin causes frontotemporal dementia (FTD), scientists created induced pluripotent stem cells from patients carrying the GRNIVS1+5G > C mutation. Although generation of neuroprogenitors was unaffected, their further differentiation into CTIP2-, FOXP2-, or TBR1-TUJ1 double-positive cortical neurons, but not motorneurons, was significantly decreased in FTD-neural progeny. [Stem Cell Rep] Full Article | Graphical Abstract | Press Release

Take the "if" out of "diff": Reduce variability when differentiating to neural progenitors
Immune Dysregulation and Cognitive Vulnerability in the Aging Brain: Interactions of Microglia, IL-1β, BDNF and Synaptic Plasticity
The author focuses on the impact of dysregulated production of interleukin (IL)-1β on hippocampus dependent-memory systems and associated synaptic plasticity processes. [Neuropharmacology] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.
23andMe and Genentech to Analyze Genomic Data for Parkinson’s Disease
23andMe, Inc. announced an agreement with Genentech to generate whole genome sequencing data for approximately 3,000 people in 23andMe’s Parkinson’s disease community. The goal of the collaboration is to identify new therapeutic targets for treating Parkinson’s disease. [23andMe Inc. (EurekAlert!)] Press Release

BrainStorm Announces Final Analysis of Phase IIa ALS Study Showing Nearly All Subjects Experienced Clinical Benefit from NurOwn™
BrainStorm Cell Therapeutics Inc. announced positive final results from its Phase IIa clinical trial of NurOwn™ in amyotrophic lateral sclerosis (ALS) patients, which enrolled 14 subjects at Hadassah Medical Center in Jerusalem. [BrainStorm Cell Therapeutics Inc.] Press Release

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Therapeutic Goods Administration (Australia)
NEW Regenerative Medicine & Stem Cell (RMSC) 2015
March 19-21, 2015
Busan, South Korea

Visit our events page to see a complete list of events in the neural cell community.
NEW Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Researcher – Epigenetic Mechanisms and Behavioral Outcomes of Developmental Neurotoxicity (Thomas Jefferson University)

NEW Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

NEW Faculty Position – Neuroscience/Membrane Proteins (National Institute of Mental Health and Neuro Sciences)

Tenure-Track Position – Cellular/Molecular Neuroscience (Carnegie Mellon University)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Fellowship – Neural Development (National Institutes of Health)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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