Volume 8.46 | Nov 26

Neural Cell News 8.46 November 26, 2014
Neural Cell News
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Pain in a Dish: Turning Skin Cells into Pain-Sensing Neurons
Researchers have successfully converted mouse and human skin cells into pain-sensing neurons that respond to a number of stimuli that cause acute and inflammatory pain. [Press release from the Harvard Stem Cell Institute discussing online prepublication in Nature Neuroscience] Press Release | Abstract
Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture. View Data!
PUBLICATIONS (Ranked by impact factor of the journal)
Selective Conversion of Fibroblasts into Peripheral Sensory Neurons
Researchers found that transiently coexpressing Brn3a with either Ngn1 or Ngn2 selectively reprogrammed human and mouse fibroblasts to acquire key properties of three classes of sensory neurons. [Nat Neurosci] Abstract | Press Release

Human Glial Chimeric Mice Reveal Astrocytic Dependence of JC Virus Infection
Engraftment of human glial progenitor cells (GPCs) in normally myelinated and immunodeficient mice resulted in humanized white matter that was chimeric for human astrocytes and GPCs. JC virus (JCV) effectively propagated in these mice, which indicates that astroglial infection is sufficient for JCV spread. [J Clin Invest] Full Article | Press Release | Video

​PKM2 Phosphorylates ​MLC2 and Regulates Cytokinesis of Tumor Cells
​Pyruvate kinase M2 (​PKM2)-regulated ​myosin light chain 2 (​MLC2) phosphorylation, which is greatly enhanced by EGF stimulation or ​EGFRvIII, ​K-Ras G12V and ​B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumor development. [Nat Commun] Abstract | Press Release

Reduced Synaptic Vesicle Protein Degradation at Lysosomes Curbs TBC1D24/sky-Induced Neurodegeneration
Researchers studied Drosophila melanogaster lacking active TBC1D24/Skywalker, a protein that in humans causes severe neurodegeneration, epilepsy, and DOOR (deafness, onychdystrophy, osteodystrophy, and mental retardation) syndrome, and identified endosome-to-lysosome trafficking as a mechanism for degradation of synaptic vesicle-associated proteins. [J Cell Biol] Abstract | Press Release

NOS1AP, a Protein Implicated in Schizophrenia, Controls Radial Migration of Cortical Neurons
To determine whether nitric oxide synthase 1 adaptor protein (NOS1AP) plays a role in cortical patterning, scientists knocked down or co-overexpressed NOS1AP and a GFP or TagRFP reporter in neuronal progenitor cells of the embryonic rat neocortex using in utero electroporation. [Biol Psychiatry] Abstract | Press Release

Suppression of Histone Deacetylation Promotes the Differentiation of Human Pluripotent Stem Cells towards Neural Progenitor Cells
Researchers demonstrate that suppression of histone deacetylases (HDACs) promoted the differentiation of human pluripotent stem cells towards neural progenitor cells (NPCs). Application of HDAC inhibitors increased the expression of neuroectodermal markers and enhanced the neuroectodermal specification once neural differentiation was initiated, thereby leading to more NPC generation. [BMC Biol] Abstract | Full Article

Human Neural Stem Cells Rapidly Ameliorate Symptomatic Inflammation in Early-Stage Ischemic-Reperfusion Cerebral Injury
Scientists tested whether exogenously engrafted human neural stem cells could migrate rapidly and extensively to damaged regions, following transplantation into a neurogenic site where migration cues are already underway during stroke onset, then counteract a number of these pathological processes. [Stem Cell Res]
Abstract | Full Article

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex
Investigators show that retrovirus-mediated expression of the transcription factors Sox2 and Ascl1, but strikingly also Sox2 alone, can induce the conversion of genetically fate-mapped NG2 glia into induced doublecortin (DCX)+ neurons in the adult mouse cerebral cortex following stab wound injury in vivo. [Stem Cell Rep] Full Article | Graphical Abstract | Editorial

Efficiently Expand hPSC-Derived NPCs Without Loss of Multipotency: STEMdiff™ Neural Progenitor Medium
Human Oligodendrocytes in Remyelination Research
The authors give a summary of studies on the generation and testing of pure suspensions of human oligodendrocytes as a clinically relevant, efficient cellular tool for treating myelin pathology. [Glia] Abstract

Stem Cell Signature in Glioblastoma: Therapeutic Development for a Moving Target
The author summarizes recent progress in the characterization of the molecular signature in distinct high-grade glioma (HGG) and glioma stem cell (GSC) subtypes and plasticity between different GSC subtypes as well as between GSCs and non-GSCs in HGG tumors. [J Neurosurg] Full Article

Visit our reviews page to see a complete list of reviews in the neural cell research field.

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Research Shows Potential of Stem Cells in Treating Brain Diseases
Scientists reported significant advances in the search for stem cell-based treatments for degenerative brain disorders, such as Huntington’s and Parkinson’s diseases. [Press release from the Society for Neuroscience discussing research presented at Neuroscience 2014, Washington, DC] Press Release

Autism Gene Needed for Growth of Neurons during Gestation
Mutations in one of the strongest autism candidate genes may block the proliferation of neurons during development. [Press release from Simons Foundation Autism Research Initiative discussing research presented at Neuroscience 2014, Washington, DC] Press Release

Immune Checkpoint Inhibitors May Work in Brain Cancers
New evidence that immune checkpoint inhibitors may work in glioblastoma and brain metastases was presented. [Press release from the European Society for Medical Oncology (ESMO) discussing research presented at the ESMO Symposium on Immuno-Oncology 2014, Geneva] Press Release

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Three UBC Professors Receive $4 Million for Alzheimer’s Research
Three University of British Columbia researchers are among the first to receive funding from the British Columbia Alzheimer’s Research Award Program. [The University of British Columbia] Press Release

Mount Sinai Researchers Awarded $1 Million Grant to Find New Stem Cell Therapies for Vision Recovery
The National Eye Institute has awarded researchers at the Icahn School of Medicine at Mount Sinai a five-year grant that will support an effort to re-create a patient’s ocular stem cells and restore vision in those blinded by corneal disease. [Mount Sinai Medical Center (Newswise, Inc.)] Press Release

Historic Brain Tumor Research Partnership Launched
The Brain Tumor Research charity and Plymouth University have established a new Research Centre of Excellence, which will focus on low grade brain tumors – some of the most overlooked forms of brain tumors. [Plymouth University] Press Release

New Alzheimer’s Program to Focus on Prevention, Intervention, Research and Support
Seeking to stem the rapid increase of Alzheimer’s disease, Cedars-Sinai has launched a new Alzheimer’s Prevention Program to help identify patients at risk of developing the neurological disorder and to reduce the impact on those diagnosed with the slow-moving condition. [Cedars-Sinai] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – Neuroinflammation in Diseases of the Central Nervous System
January 25-30, 2015
Taos, United States

NEW Advances in Brain Cancer Research
May 27-30, 2015
Washington DC, United States

Visit our events page to see a complete list of events in the neural cell community.
NEW Associate Professor – Physiology (University of Bergen)

NEW Assistant Professor – Clinical Neurology (UCSF)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Postdoctoral Scientist – Immunotherapy (Children’s Hospital of Eastern Ontario Research Institute)

Postdoctoral Fellow – Developmental, Stem Cell, and/or Cancer Biology (North Carolina State University)

Postdoctoral Position – Stem Cell Biology (Northwestern University)

Faculty Positions – Personalized Medicine (University of Nevada, Las Vegas)

Associate/Full Professor – Rudi Schmid Endowed Chair in Neuroscience (University of California, San Francisco)

Postdoctoral Candidate – Dynamic Organization of Synapses (INSERM)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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