Novel Culture System Replicates Course of Alzheimer’s Disease, Confirms Amyloid Hypothesis
Investigators realized that liquid two-dimensional systems usually used to grow cultured cells poorly represent the gelatinous three-dimensional environment within the brain. Instead they used a gel-based, three-dimensional culture system to grow human neural stem cells that carried variants in two genes, the amyloid precursor protein and presenilin 1, known to underlie early-onset familial Alzheimer’s disease. [Press release from Massachusetts General Hospital discussing online prepublication in Nature] Press Release|Abstract
Adult Neurogenesis Is Necessary to Refine and Maintain Circuit Specificity
Scientists demonstrate that eliminating adult-born interneurons in naive animals leads to an expansion of tufted cell axons that are identical to the changes caused by sensory block, revealing an essential role for new neurons in circuit maintenance under baseline conditions. [J Neurosci] Abstract|Press Release
The Phenotypic Variability of Amyotrophic Lateral Sclerosis
The authors review the phenotypic variability of amyotrophic lateral sclerosis (ALS) and how it is reflected in familial and sporadic ALS, in the degree of upper and lower motor neuron involvement, in motor and extramotor involvement, and in the spectrum of ALS and frontotemporal dementia. [Nat Rev Neurol] Abstract
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UMD Researchers Receive Grants under New Federal BRAIN Initiative
A University of Maryland/National Institute of Mental Health research team has been awarded a three-year $1.7 million grant from the National Institutes of Health to develop new imaging technologies and data analysis techniques that will further our understanding of how large networks of neurons in the brain interact to process sensory information. [University of Maryland] Press Release
Funding for Better Understanding of Neural Stem Cells
A team of scientists led by a researcher from Plymouth University has received funding of more than £400,000 from the Biotechnology and Biological Sciences Research Council to investigate how neural stem cells differ from each other. [Plymouth University] Press Release
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