Volume 8.40 | Oct 15

Neural Cell News 8.40 October 15, 2014
Neural Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  NCN on Twitter
 
TOP STORY
Novel Culture System Replicates Course of Alzheimer’s Disease, Confirms Amyloid Hypothesis
Investigators realized that liquid two-dimensional systems usually used to grow cultured cells poorly represent the gelatinous three-dimensional environment within the brain. Instead they used a gel-based, three-dimensional culture system to grow human neural stem cells that carried variants in two genes, the amyloid precursor protein and presenilin 1, known to underlie early-onset familial Alzheimer’s disease. [Press release from Massachusetts General Hospital discussing online prepublication in Nature] Press Release | Abstract
Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture. View Data!
 
PUBLICATIONS (Ranked by impact factor of the journal)
Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks
The authors propose a framework for the systematic discovery of genetic alterations that are causal determinants of disease, by prioritizing genes upstream of functional disease drivers, within regulatory networks inferred de novo from experimental data. They tested this framework by identifying the genetic determinants of the mesenchymal subtype of glioblastoma. [Cell] Abstract | Graphical Abstract | Press Release | Video

A Latent Neurogenic Program in Astrocytes Regulated by Notch Signaling in the Mouse
Investigators report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. [Science] Abstract | Press Release

​Pin1-Dependent Signaling Negatively Affects GABAergic Transmission by Modulating ​Neuroligin2/​Gephyrin Interaction
Researchers demonstrate that endogenous ​Neuroligin2 (NL2) undergoes proline-directed phosphorylation at its unique S714-P consensus site, leading to the recruitment of the peptidyl-prolyl cis-trans isomerase ​Pin1. This signaling cascade negatively regulates ​NL2’s ability to interact with ​gephyrin at GABAergic post-synaptic sites. [Nat Commun] Full Article | Press Release

Direct Evidence of Parkinson Pathology Spread from the Gastrointestinal Tract to the Brain in Rats
Investigators provide the first experimental evidence that different α-synuclein forms can propagate from the gut to the brain, and that microtubule-associated transport is involved in the translocation of aggregated α-synuclein in neurons. [Acta Neuropathol] Abstract | Press Release

Disruption of Astrocyte-Neuron Cholesterol Cross Talk Affects Neuronal Function in Huntington’s Disease
In Huntington’s disease (HD), cholesterol biosynthesis in the brain is severely reduced. Researchers show that this defect, occurring in astrocytes, is detrimental for HD neurons. [Cell Death Differ] Abstract

Dual mTORC1/2 Blockade Inhibits Glioblastoma Brain Tumor Initiating Cells In Vitro and In Vivo and Synergizes with Temozolomide to Increase Orthotopic Xenograft Survival
Human brain tumor-initiating cell lines with different combinations of endogenous EGFR wild-type, EGFRvIII, and PTEN mutations were used to investigate response to the EGFR inhibitor gefitinib, mTORC1 inhibitor rapamycin, and dual mTORC1/2 inhibitor AZD8055 alone and in combination with temozolomide. [Clin Cancer Res] Abstract | Press Release

Adult Neurogenesis Is Necessary to Refine and Maintain Circuit Specificity
Scientists demonstrate that eliminating adult-born interneurons in naive animals leads to an expansion of tufted cell axons that are identical to the changes caused by sensory block, revealing an essential role for new neurons in circuit maintenance under baseline conditions. [J Neurosci] Abstract | Press Release

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells
Investigators tested the hypothesis that maternal inflammation during critical periods of embryonic development can cause brain overgrowth and autism-associated behaviors as a result of altered neural stem cell function. [Stem Cell Rep] Full Article | Graphical Abstract | Press Release

Webinar: Brent Reynolds on Identification and Characterization of Neural Stem Cells
 
REVIEWS
The Phenotypic Variability of Amyotrophic Lateral Sclerosis
The authors review the phenotypic variability of amyotrophic lateral sclerosis (ALS) and how it is reflected in familial and sporadic ALS, in the degree of upper and lower motor neuron involvement, in motor and extramotor involvement, and in the spectrum of ALS and frontotemporal dementia. [Nat Rev Neurol] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.

Global Controls in Stem Cells
 
INDUSTRY NEWS
Four UCLA Scientists Receive NIH Innovator Award for Stem Cell, Neuroscience Research
Four scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received a National Institutes of Health (NIH) Director’s New Innovator Award for advancing revolutionary stem cell and neuroscience in medicine. [UCLA] Press Release

UMD Researchers Receive Grants under New Federal BRAIN Initiative
A University of Maryland/National Institute of Mental Health research team has been awarded a three-year $1.7 million grant from the National Institutes of Health to develop new imaging technologies and data analysis techniques that will further our understanding of how large networks of neurons in the brain interact to process sensory information. [University of Maryland] Press Release

Funding for Better Understanding of Neural Stem Cells
A team of scientists led by a researcher from Plymouth University has received funding of more than £400,000 from the Biotechnology and Biological Sciences Research Council to investigate how neural stem cells differ from each other. [Plymouth University] Press Release

First Patient Treated in Neuralstem Phase I Spinal Cord Injury Stem Cell Trial through the UC San Diego Sanford Stem Cell Clinical Center
Neuralstem, Inc. announced that the first patient was treated last week in the Phase I trial testing NSI-566 human neural stem cells in the treatment of chronic spinal cord injury at the UC San Diego School of Medicine. [Neuralstem, Inc.] Press Release

From our sponsor: Free wallchart from Nature Neuroscience – Neural Stem Cells. Request your copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Nuclear Reprogramming and the Cancer Genome 2014
October 31-November 2, 2014
Guangzhou, China

NEW 3rd Annual Cell Culture & Bioprocessing Congress 2014
November 17-18, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the neural cell community.
 
JOB OPPORTUNITIES
NEW Associate/Full Professor – Rudi Schmid Endowed Chair in Neuroscience (University of California, San Francisco)

Assistant Professor – Neurobiology (University of California, Berkeley)

Postdoctoral Research Assistant – Cell Polarity (University of Dundee)

Tenure Track Positions – Neuroscience (Albert Einstein College of Medicine / Gottesman Stem Cell Institute)

Postdoctoral Fellow – Stem Cell Research (University of Wisconsin-Madison)

Postdoctoral Fellow – Tissue Engineering & Spinal Cord Injury (Nanyang Technological University)

Postdoctoral Candidate – Dynamic Organization of Synapses (INSERM)

Postdoctoral Fellow – Stem Cell Biology (The University of Texas Medical School At Houston)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
 

Have we missed an important article or publication in Neural Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Neural Cell News: Archives | Events | Contact Us