Volume 8.32 | Aug 20

Neural Cell News 8.32 August 20, 2014
Neural Cell News
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Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells
Researchers show that changes in energy metabolism induced by the steroid hormone ecdysone and the Mediator initiate an irreversible cascade of events leading to cell-cycle exit in Drosophila neural stem cells. [Cell] Abstract | Graphical Abstract | Press Release
Efficiently Expand hPSC-Derived NPCs Without Loss of Multipotency: STEMdiff™ Neural Progenitor Medium
PUBLICATIONS (Ranked by impact factor of the journal)
Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS
Bioactive small molecules targeting RNA of the expanded repeat (r(GGGGCC)exp) were designed and found to significantly inhibit repeat-associated non-ATG translation and foci formation in cultured cells expressing r(GGGGCC)66 and neurons transdifferentiated from fibroblasts of repeat expansion carriers. [Neuron]
Abstract | Press Release

Myc Inhibition Is Effective against Glioma and Reveals a Role for ​Myc in Proficient Mitosis
Researchers preclinically validated ​Myc inhibition as a therapeutic strategy in mouse and human glioma, using a mouse model of spontaneous multifocal invasive astrocytoma and its derived neuroprogenitors, human glioblastoma cell lines, and patient-derived tumors both in vitro and in orthotopic xenografts. [Nat Commun]
Full Article | Press Release

Cells from the Immune System Generate Adult-Born Neurons in Crayfish
Researchers report that adult-born neurons in crayfish can be derived from hemocytes. Following adoptive transfer of 5-ethynyl-2′-deoxyuridine-labeled hemocytes, labeled cells populate the neurogenic niche containing the first-generation neuronal precursors. [Dev Cell] Abstract | Press Release

A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation
At early embryonic stages, high Ctbp2 levels sustain Notch signaling and radial glial expansion and concomitantly induce miR-132 expression via a double-negative feedback loop involving Rest inhibition. [Dev Cell] Abstract | Graphical Abstract | Press Release

Optogenetic Neuronal Stimulation Promotes Functional Recovery after Stroke
Researchers used optogenetics to selectively activate neurons that express channelrhodopsin 2 and demonstrated that selective neuronal stimulations in the ipsilesional primary motor cortex can promote functional recovery. [Proc Natl Acad Sci USA] Abstract | Press Release | Video

A Switch from Canonical to Noncanonical Wnt Signaling Mediates Early Differentiation of Human Neural Stem Cells
Researchers show that Wnt/AP-1 signaling drives differentiation of human embryonic stem cell and induced pluripotent stem cell-derived neural progenitor cells. [Stem Cells] Abstract

Assembly of Polyelectrolyte Multilayer Films on Supported Lipid Bilayers to Induce Neural Stem/Progenitor Cell Differentiation into Functional Neurons
A biomimetic material comprising a supported lipid bilayer with adsorbed sequential polyelectrolyte multilayer films was fabricated to induce neural stem/progenitor cells to form functional neurons without the need for serum and growth factors in a short-term culture. [ACS Appl Mater Interfaces] Abstract

Application and Assessment of Optical Clearing Methods for Imaging of Tissue-Engineered Neural Stem Cell Spheres
Scientists assessed the application of the recently published clearing techniques ClearT2, Scale, and SeeDB to tissue-engineered neural spheres. They found that scaffold-free self-assembled adult hippocampal neural stem cell spheres 100 µm in diameter could be optically cleared and imaged using either ClearT2 or Scale protocols, while SeeDB only marginally improved imaging depth. [Tissue Eng Part C Methods] Abstract

Pax6 Is Essential for the Maintenance and Multi-Lineage Differentiation of Neural Stem Cells, and for Neuronal Incorporation into the Adult Olfactory Bulb
Scientists indicated that the Paired type homeobox 6 (Pax6) mutation alters Nestin+-cell proliferation in vivo, as well as self-renewal, proliferation and survival of neural stem cells isolated from the adult olfactory bulb in vitro although a subpopulation of +/SeyDey progenitors is able to expand partially like wild type progenitors. [Stem Cells Dev] Abstract

The Snail Transcription Factor Regulates the Numbers of Neural Precursor Cells and Newborn Neurons throughout Mammalian Life
When mice containing a floxed Snail allele are crossed with Nestin-cre mice that express Cre recombinase in embryonic neural precursors, this causes inducible ablation of Snail expression throughout the postnatal cortex. This loss of Snail causes a decrease in proliferation of neonatal cortical neural precursors and mislocalization and misspecification of cortical neurons. [PLoS One] Full Article

Webinar: Brent Reynolds on Identification and Characterization of Neural Stem Cells
Endogenous Neurogenesis following Ischemic Brain Injury: Insights for Therapeutic Strategies
Scientists highlight recent advances over the last five years that help unravel the cellular and molecular mechanisms that potentiate endogenous neurogenesis following cerebral ischemia and are dissecting the functional importance of this regenerative mechanism following brain injury. [Int J Biochem Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.

13th Annual Clinical Trials in CNS Conference
Biogen Idec’s PLEGRIDY™(Peginterferon Beta-1a) Approved in the US for the Treatment of Multiple Sclerosis
Biogen Idec announced that the U.S. Food and Drug Administration (FDA) has approved PLEGRIDYTM (peginterferon beta-1a), a new treatment for people with relapsing forms of multiple sclerosis. [Biogen Idec] Press Release

Ice Bucket Challenge Still Going Strong: $31.5 Million in Donations to The ALS Association
The ALS Association has received $31.5 million in donations compared to $1.9 million during the same time period last year. These donations have come from existing donors and 637,527 new donors to the association. [The ALS Association] Press Release

From our sponsor: Free wallchart from Nature Neuroscience – Neural Stem Cells. Request your copy.
Fattah Statement on NSF Awarding $10.8 Million in EAGER Grants for Neuroscience Research
Congressman Chaka Fattah (D-PA) released a statement on the National Science Foundation’s (NSF) announcement that they have awarded $10.8 million in Early Concept Grants for Exploratory Research (EAGER) as part of the agency’s support for neuroscience. [House of Representatives] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st Stem Cell Network Workshop – Bioengineering and Stem Cells
September 23, 2014
Sydney, Australia

Visit our events page to see a complete list of events in the neural cell community.
NEW PhD Position – EphB/EphrinB in Stroke (Heidelberg University)

Postdoctoral Fellowship (Medical University of South Carolina)

Research Associate – Neuroscience (University of Cambridge)

Postdoctoral Position – Neural Extracellular Matrix (German Center for Neurodegenerative Diseases)

Postdoctoral Position – Motor Neuron Biology (Cincinnati Children’s Hospital Medical Center)

Technical Account Manager (GlobalStem)

Postdoctoral Fellow – Immunity and Neurogenesis (Karolinska Institute)

Postdoctoral Fellow – Cell Biology (Yale University)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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