Volume 8.28 | Jul 23

Neural Cell News 8.28 July 23, 2014
Neural Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  Neural Cell News on Twitter
Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
Researchers demonstrate that, in the steady state, muscularis macrophages regulate peristaltic activity of the colon. Enteric neurons, in turn, secrete colony stimulatory factor 1, a growth factor required for macrophage development. The findings identify a plastic, microbiota-driven crosstalk between muscularis macrophages and enteric neurons that controls gastrointestinal motility. [Cell] Abstract | Graphical Abstract | Press Release
Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture. View Data!
PUBLICATIONS (Ranked by impact factor of the journal)
Acid Sphingomyelinase Modulates the Autophagic Process by Controlling Lysosomal Biogenesis in Alzheimer’s Disease
Investigators show that acid sphingomyelinase (ASM) is increased in fibroblasts, brain, and/or plasma from patients with Alzheimer’s disease (AD) and in AD mice, leading to defective autophagic degradation due to lysosomal depletion. Autophagic dysfunction in neurons derived from familial AD patient induced pluripotent stem cells was restored by partial ASM inhibition. [J Exp Med] Abstract | Press Release

Multi-Scale, Hierarchically Patterned Topography for Directing Human Neural Stem Cells into Functional Neurons
Scientists developed a hierarchically patterned substrate platform that can synergistically enhance the differentiation of human neural stem cells by simultaneously providing microscale and nanoscale spatial controls to facilitate the alignment of the cytoskeleton and the formation of focal adhesions. [ACS Nano] Abstract

Role of Astroglia in Down’s Syndrome Revealed by Patient-Derived Human-Induced Pluripotent Stem Cells
Investigators used induced pluripotent stem cells derived from Down’s syndrome (DS) patients to identify a role for astrocytes in DS pathogenesis. [Nat Commun] Full Article | Press Release

prickle Modulates Microtubule Polarity and Axonal Transport to Ameliorate Seizures in Flies
Researchers show that Prickle organizes microtubule polarity and affects their growth dynamics in axons of Drosophila neurons, which in turn influences both anterograde and retrograde vesicle transport. [Proc Natl Acad Sci USA] Abstract | Press Release

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability
In the hippocampus, researchers found that perisynaptic astrocytic processes show extensive structural plasticity that is regulated by synaptic activity through astrocytic metabotropic glutamate receptors and intracellular calcium signaling. [Curr Biol] Abstract | Graphical Abstract | Press Release

Functional and Molecular Defects of hiPSC-Derived Neurons from Patients with ATM Deficiency
To investigate the mechanisms of neurodegeneration, investigators reprogrammed fibroblasts from ataxia telangiectasia mutated (ATM)-null ataxia-telangiectasia patients and normal controls to pluripotency (human-induced pluripotent stem cells [hiPSCs]), and derived from these neural precursor cells able to terminally differentiate into post-mitotic neurons positive to >90% for β-tubulin III+/microtubule-associated protein 2+. [Cell Death Dis] Full Article

Induced Pluripotent Stem Cells from Familial Alzheimer’s Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties
Researchers differentiated human induced pluripotent stem cells (hiPSC) lines to the neuronal lineage and demonstrated that hiPSC-derived neurons have mature phenotypic and physiological properties. [Stem Cells Dev] Abstract

Mechanisms of Neuroblastoma Cell Growth Inhibition by CARP-1 Functional Mimetics
Researchers investigated neuroblastoma (NB) inhibitory potential of CARP-1 functional mimetics (CFMs) and the molecular mechanisms involved. CFM-1, -4, and -5 inhibited NB cell growth, in vitro, independent of their p53 and MYCN status. [PLoS One] Full Article

Glioblastoma: A Pathogenic Crosstalk between Tumor Cells and Pericytes
Scientists investigated the underlying mechanism by which the most lethal brain cancer, glioblastoma multiforme (GBM) interacts with pre-existing blood vessels to promote tumor initiation and progression. Using mouse xenografts and laminin-coated silicone substrates, they show that GBM malignancy proceeds via specific and previously unknown interactions of tumor cells with brain pericytes. [PLoS One] Full Article

IGF-1 Enhances Cell Proliferation and Survival during Early Differentiation of Mesenchymal Stem Cells to Neural Progenitor-Like Cells
Based on previous studies of the roles of insulin-like growth factor 1 (IGF-1) in neural stem cell isolation in the laboratory, scientists hypothesized that IGF-1 can enhance proliferation and reduce apoptosis in neural progenitor-like cells (NPCs) during differentiation of mesenchymal stem cells into NPCs. [BMC Neurosci] Abstract | Full Article

Graft of the Gelatin Sponge Scaffold Containing Genetically Modified Neural Stem Cells Promotes Cell Differentiation, Axon Regeneration and Functional Recovery in Rat with Spinal Cord Transection
Investigators performed gelatin sponge scaffold seeded with neurotrophin-3 and its receptor TrkC gene modifying neural stem cells for repairing spinal cord injury. [J Biomed Mater Res A] Abstract

Your Free Copy of the Nature Neuroscience Poster 'Neural Stem Cells' Awaits
Angiogenesis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Angiogenesis, the formation of new vessels, is found in multiple sclerosis demyelinating lesions following vascular endothelial growth factor release and the production of several other angiogenic molecules. The increased energy demand of inflammatory cuffs and damaged neural cells explains the strong angiogenic response in plaques and surrounding white matter. [Acta Neuropathol Commun] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the neural cell research field.

13th Annual Clinical Trials in CNS Conference
New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice
Eli Lilly and Company announced results from its non-clinical study in genetically engineered mice examining combination therapy with the murine version of the beta-amyloid antibody N3pG and beta-secretase inhibitor BACE. [Press release from Eli Lilly and Company discussing research presented at the Alzheimer’s Association International Conference® (AAIC®) 2014, Copenhagen] Press Release

Crenezumab Phase II Cognition Data in Alzheimer’s Disease Presented
AC Immune announced the presentation of data from two Phase II studies investigating whether crenezumab (anti beta-amyloid antibody) can delay cognitive and functional decline in people with mild-to-moderate Alzheimer’s disease by its partner Genentech. [Press release from AC Immune discussing research presented at the Alzheimer’s Association International Conference® (AAIC®) 2014, Copenhagen] Press Release

Drug’s Effect on Alzheimer’s May Depend on Severity of Disease
A cancer drug that has shown promise against Alzheimer’s disease (AD) in mice and has begun early clinical trials has yielded perplexing results in a novel mouse model of AD that mimics the genetics and pathology of the human disease more closely than any other animal model. [Press release from the University of Illinois discussing research presented at the Alzheimer’s Association International Conference® (AAIC®) 2014, Copenhagen ] Press Release

From our sponsor: Free wallchart from Nature Neuroscience – Neural Stem Cells. Request your copy.
Alumnus Gives $500,000 to Fuel Neuroscience Discoveries
The Weisers’ donation of $500,000 will establish an endowment to support basic science and translational research in the neurosciences at the Geisel School of Medicine. [Trustees of Dartmouth College] Press Release

Pfizer to Acquire InnoPharma, Inc.
Pfizer Inc. and InnoPharma, Inc. announced that they have entered into an agreement under which Pfizer will acquire InnoPharma. [InnoPharma, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cancer Diagnosis at the Crossroads: Precision Medicine Driving Change
September 15-17, 2014
Seattle, United States

Visit our events page to see a complete list of events in the neural cell community.
NEW Technical Account Manager (GlobalStem)

Product Marketing Manager (Cesca Therapeutics)

Postdoctoral Fellow – Immunity and Neurogenesis (Karolinska Institute)

Postdoctoral Fellow – Cell Biology (Yale University)

Research Associate – Generation of Laminated Neural Retinae from Human Pluripotent Stem Cells (Institute of Genetic Medicine)

Postdoctoral Fellow – Experimental Neuroscience, Stem Cell Biology, and Neurotransplantation (Johns Hopkins University)

Postdoctoral Positions – Optics and Bioengineering for Engineering and/or Neuroscientific Applications (Nanyang Technological University)

Postdoctoral Position – Cellular Neuroscience (Centre National de la Recherche Scientifique – CNRS)

Postdoctoral Fellow – Molecular/Cellular Neuroscience (CIMA/University of Navarra)

Postdoctoral Position – Neurotoxicity and Epigenetics (Thomas Jefferson University)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Neural Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Neural Cell News: Archives | Events | Contact Us