Volume 8.25 | Jul 2

Neural Cell News 8.25 July 2, 2014
Neural Cell News
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First Positive Results toward a Therapeutic Vaccine against Brain Cancer
Cancer researchers developed a mutation-specific vaccine targeting a protein that is mutated in brain cancer. The researchers report that the vaccine arrested tumor growth in mice. [Press release from Heidelberg University Hospital discussing online prepublication in Nature] Press Release | Abstract
ReLeSR™, Easy Passaging Through Selective Detachment of hPSCs
PUBLICATIONS (Ranked by impact factor of the journal)
GABA from Reactive Astrocytes Impairs Memory in Mouse Models of Alzheimer’s Disease
Scientists show that reactive astrocytes aberrantly and abundantly produce the inhibitory gliotransmitter GABA by monoamine oxidase-B and abnormally release GABA through the bestrophin 1 channel. [Nat Med] Abstract

Transcription Factor Induction of Human Oligodendrocyte Progenitor Fate and Differentiation
Using FACS-based isolation and microarray analysis, investigators identified a set of transcription factors expressed by human primary CD140a+O4+ oligodendrocyte progenitor cell relative to CD133+CD140a neural stem/progenitor cells. [Proc Natl Acad Sci USA] Abstract | Press Release

Neurons in the Human Amygdala Selective for Perceived Emotion
The human amygdala plays a key role in recognizing facial emotions and neurons in the monkey and human amygdala respond to the emotional expression of faces. It remains unknown whether these responses are driven primarily by properties of the stimulus or by the perceptual judgments of the perceiver. Researchers investigated these questions by recording from over 200 single neurons in the amygdalae of seven neurosurgical patients with implanted depth electrodes. [Proc Natl Acad Sci USA] Abstract | Press Release

Caspase Inhibition in Select Olfactory Neurons Restores Innate Attraction Behavior in Aged Drosophila
Using a genetic probe for caspase-3-like activity investigators mapped age-dependent neuronal changes in the adult brain throughout the lifespan of Drosophila. [PLoS Genet] Full Article

Melatonin Reduces Endoplasmic Reticulum Stress and Preserves Sirtuin 1 Expression in Neuronal Cells of Newborn Rats after Hypoxia-Ischemia
Scientists assessed if attenuation of endoplasmic reticulum stress is involved in the neuroprotective effect of melatonin after neonatal hypoxia-ischemia (HI). Melatonin significantly reduced the neuron splicing of XBP-1 mRNA, the increased phosphorylation of eIF2α and elevated expression of chaperone proteins GRP78 and Hsp70 observed after HI in the brain. [J Pineal Res] Abstract

MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins
The author investigated the precise role of microRNA-34a (miR-34a) during neural stem cell differentiation. Their results showed that miR-34a expression was markedly downregulated during neurogenesis. [Mol Neurobiol] Abstract

PSA-NCAM+ Neural Precursor Cells from Human Embryonic Stem Cells Promote Neural Tissue Integrity and Behavioral Performance in a Rat Stroke Model
Investigators addressed the therapeutic potential of polysialic acid-neural cell adhesion molecule (PSA-NCAM)-positive neural precursor cells derived from human embryonic stem cells in a rat stroke model with permanent middle cerebral artery occlusion. [Stem Cell Rev] Abstract

Rostro-Caudal Inhibition of Hindlimb Movements in the Spinal Cord of Mice
Using optogenetic tools, investigators explored how the same population of inhibitory interneurons globally affects hindlimb movements in the spinal cord of both anesthetized and freely moving mice. [PLoS One]
Full Article | Press Release

Inhibition of Notch Signaling Facilitates the Differentiation of Human-Induced Pluripotent Stem Cells into Neural Stem Cells
The authors successfully generated neural stem cells from human induced pluripotent stem cells using serum-free medium supplemented with retinoic acid in vitro. They then assessed changes in the expression of Notch signaling-related molecules and some miRNAs (9, 34a, 200b), which exert their regulation by targeting Notch signaling. [Mol Cell Biochem] Abstract

Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors
Scientists characterized the functional differentiation of human fetal hippocampus-derived neural stem/progenitor cells-namely, HIP-009 cells. Calcium rise assay demonstrated that, after a 4-week differentiation, the cells responded to N-methyl-D-aspartate, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, or kainic acid in a concentration-dependent manner. [J Biomol Screen] Abstract

Culture primary neurons independent of substrate with NeuroCult™ SM2
Macrophage Subsets and Microglia in Multiple Sclerosis
The prime focus of this review is on multiple sclerosis, which is characterized by inflammation, demyelination, neurodegeneration, and CNS repair, and in which microglia and macrophages have been extensively scrutinized. [Acta Neuropathol] Abstract

Visit our reviews page to see a complete list of reviews in the neuroscience field.

Cell Culture World Congress Asia 2014
Agenus Brain Cancer Vaccine Shows Extended Survival in Phase II Final Data Analysis
Agenus Inc. announced final results from a single-arm, multi-institutional, open-label, Phase II study showing that patients with newly diagnosed glioblastoma multiforme who received Agenus’ Prophage autologous cancer vaccine added to the standard of care treatment, lived nearly twice as long as expected. [Agenus Inc.]
Press Release

PLOS Launches Neuroscience and Synthetic Biology Channels to Support Collaboration and Discussion of Published Research
PLOS launched an initiative designed to engage the larger scientific community in researcher-led, informal discussions of published articles and timely issues affecting researchers such as data sharing, research ethics and funding. The first two launched in a planned series of discipline-specific channels of content and activity – PLOS Neuroscience Community and PLOS Synthetic Biology Community. [Public Library of Science (PLOS)]
Press Release

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NEW Best of American Society of Clinical Oncology (ASCO) Chicago
August 15-16, 2014
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Visit our events page to see a complete list of events in the neural cell community.
NEW Research Associate – Generation of Laminated Neural Retinae from Human Pluripotent Stem Cells (Institute of Genetic Medicine)

Postdoctoral Researcher – Human Embryonic Stem Cell Differentiation in Parkinson’s Disease (VIB Center for the Biology of Disease)

Postdoctoral Fellow – Experimental Neuroscience, Stem Cell Biology, and Neurotransplantation (Johns Hopkins University)

Postdoctoral Positions – Optics and Bioengineering for Engineering and/or Neuroscientific Applications (Nanyang Technological University)

Postdoctoral Position – Cellular Neuroscience (Centre National de la Recherche Scientifique – CNRS)

Postdoctoral Scientist – Neural Stem Cells (Texas Biomedical Research Institute)

Postdoctoral Fellow – Molecular/Cellular Neuroscience (CIMA/University of Navarra)

Postdoctoral Position – Neurotoxicity and Epigenetics (Thomas Jefferson University)

Max Planck Research Group Leader – Neuroscience (Center of Advanced European Studies and Research – Caesar)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Fellow – Neurophysiology of Addiction (Medical University of South Carolina)

Postdoctoral Position – Spinal Cord Adult Neural Stem Cells (INSERM Institute for Neuroscience)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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