Volume 8.18 | May 14

Neural Cell News 8.18 May 14, 2014
Neural Cell News
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New Research May Explain Loss of Early Childhood Memories
Researchers demonstrated that new neuron formation, or neurogenesis, in the area of the brain where memories are stored, called the hippocampus, is associated with memory loss. The study found that increased neurogenesis results in more forgotten memories. [Press release from The Hospital for Sick Children discussing online prepublication in Science] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
CFIm25 Links Alternative Polyadenylation to Glioblastoma Tumor Suppression
Researchers identified CFIm25 as a broad repressor of proximal poly(Archive) site usage that, when depleted, increases cell proliferation. Downregulation of CFIm25 expression in glioblastoma cells enhances their tumorigenic properties and increases tumor size, whereas CFIm25 overexpression reduces these properties and inhibits tumor growth. [Nature] Abstract | Press Release

Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation
Miniature neurotransmission is the transsynaptic process where single synaptic vesicles spontaneously released from presynaptic neurons induce miniature postsynaptic potentials. Researchers showed that miniature neurotransmission is required for the normal structural maturation of Drosophila glutamatergic synapses in a developmental role that is not shared by evoked neurotransmission. [Neuron]
Abstract | Full Article | Press Release | Video

Mitochondrial Oxidant Stress in Locus Coeruleus Is Regulated by Activity and Nitric Oxide Synthase
Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson’s disease. To explore possible physiological determinants, scientists studied LC neurons using electrophysiological and optical approaches in ex vivo mouse brain slices. They found that autonomous activity in LC neurons was accompanied by oscillations in dendritic Ca2+ concentration that were attributable to the opening of L-type Ca2+ channels. [Nat Neurosci] Abstract

Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-Catenin
Researchers described a novel role for ankyrin-G in neural progenitor proliferation in the developing cortex. They found that ankyrin-G regulates canonical Wnt signaling by altering the subcellular localization and availability of β-catenin in proliferating cells. [Mol Psychiatry] Abstract

Specific Ablation of Nampt in Adult Neural Stem Cells Recapitulates Their Functional Defects during Aging
Investigators showed that levels of NAD+ and nicotinamide phosphoribosyltransferase (Nampt), the rate‐limiting enzyme in mammalian NAD+ biosynthesis, decrease with age in the hippocampus. Ablation of Nampt in adult neural stem/progenitor cells reduced their pool and proliferation in vivo. [EMBO J] Abstract | Press Release

Gastrin-Releasing Peptide Contributes to the Regulation of Adult Hippocampal Neurogenesis and Neuronal Development
Researchers hypothesize that gastrin-releasing peptide modulates neurogenesis and neuronal development, and may contribute to hippocampus-associated cognitive impairment. [Stem Cells] Abstract

Nitric Oxide-Induced Neuronal to Glial Lineage Fate-Change Depends on NRSF/REST Function in Neural Progenitor Cells
The authors demonstrated that the nitric oxide-induced neuronal to glial fate conversion is dependent on the transcription factor NRSF/REST. [Stem Cells] Abstract

The Synthetic NCAM Mimetic Peptide FGL Mobilizes Neural Stem Cells In Vitro and In Vivo
The neural cell adhesion molecule (NCAM) mimetic peptide FG Loop (FGL) promotes neuronal survival in vitro and enhances spatial learning and memory in rats. Researchers investigated the effects of FGL on neural stem cells in vitro and in vivo. [Stem Cell Rev] Abstract

Efficiently Expand hPSC-Derived NPCs Without Loss of Multipotency: STEMdiff™ Neural Progenitor Medium
Histone Methylation during Neural Development
Researchers summarized the current knowledge of histone methylation processes during neural development and provided insights into the function of histone methylation enzymes and their role during central nervous system development. [Cell Tissue Res] Abstract

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$4 Million from Eli and Edythe Broad Foundation Will Support UCLA Research
Two new gifts from The Eli and Edythe Broad Foundation to UCLA totaling $4 million will fund research in stem cell science and digestive diseases and support the recruitment of key faculty at two renowned research centers. [UCLA] Press Release

Xcelthera Inc Secures First U.S. Patent for Large-Scale Production of High Quality Human Embryonic Stem Cells and Their Neuronal and Heart Muscle Cell Therapy Products
Xcelthera Inc and its joint research partner San Diego Regenerative Medicine Institute announced that the U.S. Patent and Trademark Office has granted Patent No. 8,716,017 entitled, “Technologies, Methods, and Products of Small Molecule-Directed Tissue and Organ Regeneration from Human Pluripotent Stem Cells.” This newly-issued patent is the first among a portfolio of intellectual property of Xcelthera Inc covering PluriXcel human stem cell technology platform for large-scale production of high quality clinical-grade pluripotent human embryonic stem cell lines and their functional human neuronal and heart muscle cell therapy products. [Vocus PRW Holdings, LLC] Press Release

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NEW 2014 International Society for the Cell and Gene Therapy of Cancer (ISCGT) Annual Meeting
September 25-27, 2014
Amsterdam, The Netherlands

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NEW Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

NEW Postdoctoral Position – Stem Cell Biology (University of Wisconsin – Madison)

Postdoctoral Fellow – Neurophysiology of Addiction (Medical University of South Carolina)

Postdoctoral Research Associate – Molecular Neuroscience (Wellcome Trust-MRC Institute of Metabolic Science)

Postdoctoral Position – Functional Characterization of Neurons Derived from Human Pluripotent Stem Cells (Radboud University Nijmegen)

Postdoctoral Position – Spinal Cord Adult Neural Stem Cells (INSERM Institute for Neuroscience)

Postdoctoral Fellow – Stem Cell Biology, Neuroscience, Parkinson’s Research (Tulane University)

Postdoctoral Fellow / Senior Research Associate – Neural Stem Cells (The University of Hong Kong)

Postdoctoral Fellow – Neural Stem Cells and Regeneration (UT Southwestern Medical Center)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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