Volume 8.12 | Apr 2

Neural Cell News 8.12 April 2, 2014
Neural Cell News
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Patches of Cortical Layers Disrupted During Early Brain Development in Autism
Researchers have published a study that gives clear and direct new evidence that autism begins during pregnancy. The study found that in the brains of children with autism, key genetic markers were absent in brain cells in multiple layers. [Press release from the University of California, San Diego discussing online prepublication in The New England Journal of Medicine] Press Release | Abstract | Video
Culture Human Glioma-Derived Tumorspheres with NeuroCult™ - View Publications
PUBLICATIONS (Ranked by impact factor of the journal)
Cystathionine γ-Lyase Deficiency Mediates Neurodegeneration in Huntington’s Disease
Investigators showed a major depletion of cystathionine γ-lyase (CSE), the biosynthetic enzyme for cysteine, in Huntington’s disease tissues, which may mediate Huntington’s disease pathophysiology. Consistent with the notion of loss of CSE as a pathogenic mechanism, supplementation with cysteine reverses abnormalities in cultures of Huntington’s disease tissues and in intact mouse models of Huntington’s disease, suggesting therapeutic potential. [Nature] Abstract | Press Release

Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma
Researchers found that pemetrexed and gemcitabine preferentially inhibited Group3 medulloblastoma (G3 MB) proliferation in vitro compared to control neurospheres and substantially inhibited G3 MB proliferation in vivo. When combined, these two drugs significantly increased survival of mice bearing cortical implants of mouse and human G3 MBs that overexpress MYC compared to each agent alone, while having little effect on mouse MBs of the sonic hedgehog subgroup. [Cancer Cell] Abstract | Press Release

Astrocyte Kir4.1 Ion Channel Deficits Contribute to Neuronal Dysfunction in Huntington’s Disease Model Mice
Researchers found that symptom onset in R6/2 and Q175 Huntington’s disease mouse models was not associated with classical astrogliosis, but was associated with decreased Kir4.1 K+ channel functional expression, leading to elevated in vivo striatal extracellular K+, which increased striatal medium spiny neuron excitability in vitro. [Nat Neurosci] Abstract | Press Release

Phenotypic Differences in hiPSC NPCs Derived from Patients with Schizophrenia
Researchers report that a significant fraction of the gene signature of schizophrenia (SZ) human-induced pluripotent stem cell (hiPSC)-derived neurons is conserved in SZ hiPSC neural progenitor cells (NPCs). [Mol Psychiatry] Full Article

PCAF-Dependent Epigenetic Changes Promote Axonal Regeneration in the Central Nervous System
Researchers showed through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. [Nat Commun] Abstract | Press Release

Intracellular mGluR5 Can Mediate Synaptic Plasticity in the Hippocampus
To determine whether metabotropic glutamate receptor 5 (mGluR5) signals from intracellular membranes of other cell types, such as excitatory pyramidal neurons in the hippocampus, researchers used dissociated rat CA1 hippocampal cultures and slice preparations to localize and characterize endogenous receptors. [J Neurosci] Abstract | Press Release

L-Serine Treatment May Improve Neurorestoration of Rats after Permanent Focal Cerebral Ischemia Potentially through Improvement of Neurorepair
The authors found that L-serine treatment in permanent middle cerebral artery occlusion rats can reduce brain injury and facilitate neurorestoration which is partly associated with the improvement of proliferation of neural stem cells and microvessels, reconstruction of neurovascular units and resultant neurorepair. [PLoS One]
Full Article

Human Fetal Striatum-Derived Neural Stem (NS) Cells Differentiate to Mature Neurons In Vitro and In Vivo
Scientists described the isolation of a new cell line from human fetal striatum. These cells showed properties of NS cells in vitro such as monolayer growth, high proliferation rate and expression of radial glia markers. [Curr Stem Cell Res Ther] Abstract

GABA and 5-HT Chitosan Nanoparticles Decrease Striatal Neuronal Degeneration and Motor Deficits during Liver Injury
GABA and 5-HT chitosan nanoparticles mediated liver cell proliferation influenced by growth factor and cytokines and neuronal survival in corpus striatum of partially hepatectomised rats was evaluated. [J Mater Sci Mater Med] Abstract

In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Bioluminescence Imaging
Researchers employed bioluminescence imaging to track luciferase-expressing human neural progenitor cells in the rat striatum long-term. [J Neurosci Methods] Abstract

Webinar: Brent Reynolds on Identification and Characterization of Neural Stem Cells
Transport and Diffusion of Tau Protein in Neurons
This review discusses different mechanisms that have been proposed to contribute to the dispersion of Tau molecules in neurons. [Cell Mol Life Sci] Abstract

Reelin, Neuronal Polarity and Process Orientation of Cortical Neurons
This review summarizes and discusses recent findings on the role of reelin in modulating polarization and process orientation of neurons in the neocortex and hippocampus. [Neuroscience] Abstract

Visit our reviews page to see a complete list of reviews in the neuroscience field.
IntelliCell Biosciences Announces That It Is Collaborating with the Global Alliance for Innovation in Neuroscience, Inc. (GAIN) for Autism, Dementia and Brain Trauma
IntelliCell Biosciences, Inc. announced that it will be entering into a collaboration with GAIN to use its unique approach to the harvest and use of autologous adipose derived mesenchymal stem cells for clinical neuroscience applications including autism, dementia and brain trauma. [Marketwire L.P.] Press Release

Exploring the Brain for Keys to Solving Parkinson’s Disease
James M. Tepper’s territory is the striatum, the largest portion of the basal ganglia, a set of structures below the cerebral cortex involved in voluntary motor behavior as well as cognition, learning and memory, emotion and motivation. Parkinson’s disease can progressively degrade many of those functions, a primary reason why the National Institutes of Health awarded Tepper a five-year, $3.4 million grant to delve ever more deeply into the circuitry and function of the striatum. [Rutgers, The State University of New Jersey] Press Release

$2.5 Million Defense Department Grant Funds Gene Therapy Study for Lou Gehrig’s Disease
The Cedars-Sinai Regenerative Medicine Institute has received a $2.5 million grant from the Department of Defense to conduct animal studies that, if successful, could provide the basis for a clinical trial of a gene therapy product for patients with Lou Gehrig’s disease, also called amyotrophic lateral sclerosis, or ALS. [Cedars-Sinai] Press Release

NIH Celebrates Grand Opening of John Edward Porter Neuroscience Research Center
The National Institutes of Health (NIH) will host a scientific symposium and a dedication ceremony to celebrate the completion of the John Edward Porter Neuroscience Research Center. This state of the art facility brings together neuroscientists from 10 institutes and centers across the NIH in an effort to spur new advances in our understanding of the nervous system in health and disease. [National Institutes of Health] Press Release

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NEW Neuroscience 2014: Society for Neuroscience 44th Annual Meeting
November 15-19, 2014
Washington, DC, United States

Visit our events page to see a complete list of events in the neural cell community.
NEW Postdoctoral Position – Developmental Neurobiology (The Vision Institute)

NEW Postdoctoral Research Fellow / Research Officer – Stem Cell Research (Bioprocessing Technology Institute)

NEW Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Neural Stem Cells and Regeneration (UT Southwestern Medical Center)

Postdoctoral Fellow – Neuroscience & Cell Biology (Harvard Medical School)

Postdoctoral Fellow – Neurobiology (Italian Institute of Technology – IIT)

Postdoctoral Positions – Cellular Neuroscience and Autism (University of Edinburgh)

PhD Student Position – Retinal Research (Universität Tübingen)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Cell Culture Specialist – Manufacturing of Cell Therapy Products (Tisch MS Research Center of New York)

Postdoctoral Position – Neurobiology & Alzheimer’s Disease (Tel Aviv University)

Assistant/Associate Professors – Allergic Inflammation and Sensory Neurobiology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Researcher – Pathogenesis of Amyotrophic Lateral Sclerosis (VIB Vesalius Research Center Belgium)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

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