Volume 7.39 | Oct 2

Neural Cell News 7.39 October 2, 2013
Neural Cell News
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Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression
Excitatory synaptic function of CA1 neurons with recent in vivo Arc induction (ArcGFP+) was similar to neighboring noninduced neurons. However, in response to group 1 metabotropic glutamate receptor activation, ArcGFP+ neurons preferentially displayed long-term synaptic depression and robust increases in dendritic Arc protein. [Neuron] Abstract | Full Article
Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture. View Data!
PUBLICATIONS (Ranked by impact factor of the journal)
MicroRNA-17-92 Cluster Is a Direct Nanog Target and Controls Neural Stem Cells through Trp53inp1
Nanog controls microRNA (miR)-17-92 cluster by binding to the upstream regulatory region and maintaining high levels of transcription in neural stem cells, whereas Nanog/promoter association and cluster miRNAs expression are lost alongside differentiation. [EMBO J] Full Article

Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-Like Kinases
Researchers showed that CD15+ cells progress more rapidly through the cell cycle than CD15 cells and contain an increased proportion of cells in G2-M, suggesting that they might be vulnerable to inhibitors of this phase. Indeed, exposure of tumor cells to inhibitors of Aurora kinase and Polo-like kinases, key regulators o- G2-M, induces cell-cycle arrest, apoptosis, and enhanced sensitivity to conventional chemotherapy. [Cancer Res] Abstract | Press Release

Inhibition of Monocarboxylate Transporter-4 Depletes Stem-Like Glioblastoma Cells and Inhibits Hypoxia-Inducible Factor Transcriptional Response in a Lactate-Independent Manner
To test the requirement for monocarboxylate transporter-4 (MCT4) in vitro, researchers transduced neurospheres with lentiviruses encoding short-hairpin RNAs against MCT4, resulting in growth inhibition of 50-80% under hypoxia in two lines. MCT4 knockdown was associated with a decreased percentage of cells expressing the stem-cell marker CD133 and increased apoptotic fraction. [Oncogene] Abstract

Pax6 Mediates ß-Catenin Signaling for Self-Renewal and Neurogenesis by Neocortical Radial Glial Stem Cells
Investigators showed that genetic ablation of ß-catenin with hGFAP-Cre mice inhibits neocortical formation by disrupting radial glial development. [Stem Cells] Abstract

cAMP Promotes the Differentiation of Neural Progenitor Cells In Vitro via Modulation of Voltage-Gated Calcium Channels
Scientists investigated the role of Ca2+ and cAMP (cyclic adenosine monophosphate) in the differentiation of neural progenitor cells extracted from the subventricular zone of E14.5 rat embryos. Patch clamp recordings revealed that increasing cAMP-signaling with Forskolin or IBMX significantly facilitated neuronal functional maturation. [Front Cell Neurosci] Abstract

Thymoquinone Protects Cultured Hippocampal and Human Induced Pluripotent Stem Cells-Derived Neurons against α-Synuclein-Induced Synapse Damage
Researchers report that α-synuclein decreased the level of synaptophysin, a protein used as an indicator of synaptic density, in cultured hippocampal and human induced pluripotent stem cell-derived neurons. [Neurosci Lett] Abstract

Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia
Scientists explored the hypothesis that conserved dopamine neurotrophic factor, a secretory neurotrophic factor, may provide a novel therapy for associated with neuroinflammation related to microglia. [J Mol Neurosci] Abstract

Basic Fibroblast Growth Factor (bFGF) Facilitates Differentiation of Adult Dorsal Root Ganglia-Derived Neural Stem Cells toward Schwann Cells by Binding to FGFR-1 through MAPK/ERK Activation
Considerable research has been devoted to unraveling the regulation of neural stem cell (NSC) differentiation. The responses of NSCs to various differentiation-inducing stimuli, however, are still difficult to estimate. Researchers aimed to search for a potent growth factor that was able to effectively induce differentiation of NSCs toward Schwann cells. [J Mol Neurosci] Abstract

Dendritic Glutamate Receptor mRNAs Show Contingent Local Hotspot-Dependent Translational Dynamics
Scientists showed that the protein translational activities of two dendritically localized mRNAs are spatiotemporally complex but constrained by the translational hotspots in which they are colocalized. [Cell Rep] Full Article | Graphical Abstract | Press Release

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate
Using nonhuman primates, researchers found that the autologous transplantation of induced pluripotent stem cells (iPSC)-derived neurons elicited only a minimal immune response in the brain. [Stem Cell Rep]
Full Article | Graphical Abstract | Press Release

Open Access JoVE Protocol: Discriminating NSCs from NPCs with the NeuroCult™ NCFC Assay
Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
The authors highlight the functions and mechanisms of Hox gene networks and their multifaceted roles during neuronal specification and connectivity. [Neuron] Full Article

Microglia Actions in Alzheimer’s Disease
The identification of microglia-associated, neurological disease-causing mutations in patients, combined with studies in mouse models has highlighted microglia, the brain’s intrinsic myeloid cells, as key modulators of pathogenesis and disease progression in neurodegenerative diseases. [Acta Neuropathol] Abstract

Cell-Based Reparative Therapies for Multiple Sclerosis
The strong rationale for cell-based therapy in multiple sclerosis is based on the ability of stem and precursor cells of neural and mesenchymal origin to attenuate neuroinflammation, to facilitate endogenous repair processes, and to participate directly in remyelination, if directed towards a myelin-forming fate. [Curr Neurol Neurosci Rep] Abstract

Visit our reviews page to see a complete list of reviews in the neuroscience field.

Stem Cell Society Singapore 2013 Symposium
RIC Research Scientist Receives Prestigious $9 Million NIH Grant; Will Collaborate with ‘Dream Team’ of Harvard, MIT in Advanced Brain Research
The National Institutes of Health (NIH) awarded Konrad Kording, Ph.D., research scientist at the Rehabilitation Institute of Chicago (RIC), a $9 million, five-year NIH Transformative Research Award to build a non-invasive, molecular-biologic tool to record, measure and study how the brain really works. [PR Newswire Association LLC] Press Release

National Cancer Institute Awards $48.6 Million Grant to MD Anderson
Broad, deep and outstanding research in cancer science, treatment and prevention have earned The University of Texas MD Anderson Cancer Center a $48.6-million, five-year grant from the National Cancer Institute and an “exceptional” ranking, the highest possible, from the National Cancer Institute’s extensive peer-review process. [The University of Texas MD Anderson Cancer Center] Press Release

From our sponsor:
Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.
US Government Shuts Down
The US government entered a state of suspended animation on 1 October after Congress failed to agree on a budget for the next fiscal year, causing federal agencies – including those overseeing science policy and research – to shut down indefinitely. Most government scientists were ordered to stay at home, their offices and labs closed or run by a skeleton staff of ‘essential’ workers. The National Institutes of Health and the National Science Foundation stopped processing grants, some government websites were made inaccessible and many important research programmes were left hanging, potentially putting lives at risk in the case of some disease studies. [Nature Magazine] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 23rd Neuropharmacology Conference 2013
November 7-8, 2013
San Diego, United States

Visit our events page to see a complete list of events in the neural cell community.
NEW Manufacturing Manager (StemCells Inc.)

NEW PhD Research Project – Neural Stem Cell Research (University of Southampton)

Postdoctoral Fellow – Brain Cancer (Vanderbilt University Medical Center)

PhD Studentship – Neuroscience (Tübingen University)

Research Associate – Molecular Developmental Biologist (University College London)

Postdoctoral Fellowship – Neural Stem Cells (University of Wisconsin – Madison)

Postdoctoral Position – Glia and Neural Stem/Progenitor Cell Interactions (University of Kentucky College)

Tenure-Track Faculty Position – Neuroscience (University of Utah)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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