Volume 7.26 | Jul 3

Neural Cell News 7.26 July 3, 2013
Neural Cell News
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TOP STORY
Genetic and Neural Mechanisms that Inhibit Drosophila from Mating with Other Species
Investigators found that the chemoreceptor Gr32a inhibits male D. melanogaster from courting diverse fruit fly species. Gr32a and Male-specific Fruitless (FruM) are not coexpressed, but FruM neurons contact Gr32a neurons, suggesting that these genes influence a shared neural circuit that inhibits interspecies courtship. [Cell] Abstract | Graphical Abstract | Full Article | Audio Clip | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
The Chromatin Remodeler CHD7 Regulates Adult Neurogenesis via Activation of SoxC Transcription Factors
Scientists demonstrated that the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7), a protein frequently mutated in human CHARGE syndrome, is a master regulator of neurogenesis in mammalian brain. CHD7 is selectively expressed in actively dividing neural stem cells and progenitors. [Cell Stem Cell] Abstract | Graphical Abstract

The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex
In the developing neocortex, progenitor cells expand through symmetric division before they generate cortical neurons through multiple rounds of asymmetric cell division. Researchers showed that the orientation of the mitotic spindle plays a crucial role in regulating the transition between those two division modes. They demonstrated that the protein phosphatase PP4c regulates spindle orientation in early cortical progenitor cells. [Neuron] Abstract | Full Article

Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
Scientists used a monosynaptic rabies virus system to generate brain-wide maps of neurons that form synapses with direct- or indirect-pathway striatal projection neurons. They discovered that sensory cortical and limbic structures preferentially innervated the direct pathway, whereas motor cortex preferentially targeted the indirect pathway. [Neuron] Abstract | Press Release

Arl13b-Regulated Cilia Activities Are Essential for Polarized Radial Glial Scaffold Formation
Using developmental stage-specific deletion of Arl13b in mouse cortical progenitors, researchers found that early neuroepithelial deletion of ciliary Arl13b led to a reversal of the apical-basal polarity of radial progenitors and aberrant neuronal placement. [Nat Neurosci] Abstract | Press Release

a-Tanycytes of the Adult Hypothalamic Third Ventricle Include Distinct Populations of FGF-Responsive Neural Progenitors
Investigators identified a-tanycytes as key components of a hypothalamic niche in the adult mouse. In vitro studies demonstrated that a-tanycytes, but not ß-tanycytes or parenchymal cells, are neurospherogenic. Distinct subpopulations of a-tanycytes exist, amongst which only GFAP-positive dorsal a2-tanycytes possess stem-like neurospherogenic activity. [Nat Commun] Full Article | Press Release

Severing and End-to-End Annealing of Neurofilaments in Neurons
Researchers have shown previously that neurofilaments and vimentin filaments expressed in nonneuronal cell lines can lengthen by joining ends in a process known as “end-to-end annealing.” To test if this also occurs for neurofilaments in neurons, they transfected cultured rat cortical neurons with fluorescent neurofilament fusion proteins and then used photoconversion or photoactivation strategies to create distinct populations of red and green fluorescent filaments. [Proc Natl Acad Sci USA] Abstract

Histone Deacetylase 5 Blocks Neuroblastoma Cell Differentiation by Interacting with N-Myc
Researchers showed that N-Myc upregulated histone deacetylase 5 (HDAC5) expression in neuroblastoma cells. Conversely, HDAC5 repressed the ubiquitin-protein ligase NEDD4 gene expression, increased Aurora A gene expression and consequently upregulated N-Myc protein expression. [Oncogene] Abstract

Mcl1 Regulates the Terminal Mitosis of Neural Precursor Cells in the Mammalian Brain through p27Kip1
Scientists showed in mice that myeloid cell leukemia 1 (Mcl1), an anti-apoptotic Bcl-2 protein required for the survival of neural precursor cell, also regulates their terminal differentiation through the cell cycle regulator p27Kip1. [Development] Abstract

MicroRNA-195 Targets ADP-Ribosylation Factor-Like Protein 2 to Induce Apoptosis in Human Embryonic Stem Cell-Derived Neural Progenitor Cells
Scientists defined the proapoptotic role of microRNA-195 (miR-195) in neural progenitor cells (NPCs) derived from two independent human embryonic stem cell (hESC) lines. Overexpression of miR-195 in hESC-NPCs induced extensive apoptotic cell death. [Cell Death Dis] Full Article

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway
Researchers revealed that BACE1 directly regulates the level of membrane-anchored full-length Jagged1 (Jag1), a signaling molecule important for the control of neurogenesis and astrogenesis, via interaction with its cognate Notch receptor. They showed that shedding of Jag1 is reduced in BACE1 null mice and upregulated Jag1 enhances Notch signaling via cell-cell juxtacrine interactions. [Cell Rep]
Abstract | Graphical Abstract | Full Article

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REVIEWS
Iron Metabolism in the CNS: Implications for Neurodegenerative Diseases
Brain iron accumulation is observed in the globus pallidus and other brain regions in neurodegeneration with brain iron accumulation diseases, which are often associated with severe dystonia and gait abnormalities. Only two of these diseases, aceruloplasminaemia and neuroferritinopathy, are directly caused by abnormalities in iron metabolism, mainly in astrocytes and neurons, respectively. Understanding the early molecular pathophysiology of these diseases should aid insights into the role of iron and the design of specific therapeutic approaches. [Nat Rev Neurosci] Abstract

Mature Neurons: Equipped for Survival
As many neurodegenerative diseases afflict adult neuronal populations, the survival mechanisms in mature neurons are likely to be either reversed or circumvented during neurodegeneration. Examining the adaptations for inhibiting apoptosis during neuronal maturation is key to comprehending not just how neurons survive long term, but may also provide insight for understanding how neuronal toxicity in various neurodegenerative diseases may ultimately lead to cell death. [Cell Death Dis] Full Article

Visit our reviews page to see a complete list of reviews in the neuroscience field.
 
INDUSTRY NEWS
Novartis Exelon® Patch Now FDA Approved to Treat Patients across All Stages of Alzheimer’s Disease
The US Food and Drug Administration has expanded the approved indication for Exelon® Patch to include the treatment of people with severe Alzheimer’s disease (AD) with Exelon Patch. Exelon Patch is now the first and only transdermal therapy approved to treat patients with mild, moderate and severe AD. [PR Newswire Association LLC] Press Release

Parkinson’s Disease Foundation Awards $1 Million to Help Reveal Causes, Advance Therapies and End Parkinson’s
The Parkinson’s Disease Foundation® announced $1 million in funding for 14 global research projects designed to improve the lives and futures of people touched by Parkinson’s disease. [The Parkinson’s Disease Foundation] Press Release

National MS Society Commits $2.5 Million for Research by Pediatric MS Network
The National Multiple Sclerosis (MS) Society has just committed $2.5 million to support research by the Network of Pediatric MS Centers beginning July 1, 2013. Funding for the nine-center network provides essential infrastructure to facilitate research, including searching for the cause of MS by studying risk factors for the disease in children, close to the time of exposure. [The National Multiple Sclerosis Society]
Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2013 6th International IEEE/EMBS Conference on Neural Engineering
November 5-8, 2013
San Diego, United States

Visit our events page to see a complete list of events in the neural cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Fellow – Neural Plasticity (National Institute of Neurological Disorders and Stroke, NIH)

Postdoctoral Research Assistant – Dynamics of Cell Polarity (University of Dundee, College of Life Sciences)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Position – Developmental Neurobiology (North Carolina College of Veterinary Medicine)

Postdoctoral Position – Neurobiology (Weizmann Institute of Science)

PhD Opportunity – Role of Fibroblast Growth Factors in the Generation of Neuronal Diversity in the Spinal Cord (University of East Anglia)


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