Volume 7.00 | Jan 2

Neural Cell News 7.00 January 2, 2013
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NLRP3 Is Activated in Alzheimer’s Disease and Contributes to Pathology in APP/PS1 Mice
Scientists showed that NLRP3 inflammasome deficiency skewed microglial cells to an M2 phenotype and resulted in the decreased deposition of amyloid-β in the APP/PS1 model of Alzheimer’s disease. [Nature] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

Tangentially Migrating Neurons Assemble a Primary Cilium that Promotes Their Reorientation to the Cortical Plate
Investigators report that the mother centriole of neurons migrating tangentially from the medial ganglionic eminence assembles a short primary cilium and exposes this cilium to the cell surface by docking to the plasma membrane in the leading process. [Cell] Abstract

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain
The authors showed that augmented actin retrograde flow and protrusion dynamics facilitate neurite formation. [Neuron] Abstract | Press Release

Activity-Dependent Transcriptional Regulation of M-Type (Kv7) K+ Channels by AKAP79/150-Mediated NFAT Actions
Scientists discovered a mechanism regulating KCNQ2/3 transcriptional expression by neuronal activity in rodent neurons, involving activation of calcineurin and nuclear factor of activated T cell (NFAT) transcription factors, orchestrated by A kinase-anchoring protein (AKAP)79/150. [Neuron] Abstract | Press Release

Brain Endogenous Liver X Receptor Ligands Selectively Promote Midbrain Neurogenesis
Liver X receptors (Lxrα and Lxrβ) are ligand-dependent nuclear receptors critical for ventral midbrain neurogenesis in vivo. However, no endogenous midbrain Lxr ligand has so far been identified. Here, investigators used LC/MS and functional assays to identify cholic acid as a new Lxr ligand. [Nat Chem Biol] Abstract | Press Release

Essential Role of Postsynaptic NMDA Receptors in Developmental Refinement of Excitatory Synapses
Researchers demonstrated that pruning and strengthening of immature synapses are blocked in neurons without NMDA receptors (NMDARs), but occur normally in neighboring neurons with NMDARs. [Proc Natl Acad Sci USA] Abstract | Press Release

RNA Binding Ability of FUS Regulates Neurodegeneration, Cytoplasmic Mislocalization and Incorporation into Stress Granules Associated with FUS Carrying ALS-Linked Mutations
Scientists exploited a Drosophila model of amyotrophic lateral sclerosis (ALS) and neuronal cell lines to elucidate the role of the RNA-binding ability of FUS in regulating FUS-mediated toxicity, cytoplasmic mislocalization and incorporation into stress granules. [J Biol Chem] Abstract | Press Release

Pioneer Glutamatergic Cells Develop into a Morpho-Functionally Distinct Population in the Juvenile CA3 Hippocampus
Scientists investigated the network function of CA3 glutamatergic neurons from a developmental viewpoint, without fast GABAergic transmission. They uncovered a sub-population of early-generated glutamatergic neurons that impacts network dynamics when stimulated in the juvenile hippocampus. [Nat Commun]
Full Article

Regulation of Neural Progenitor Cell Proliferation by D609: Potential Role for Extracellular-Signal Regulated Kinase
Tricyclodecan-9-yl-xanthogenate (D609) has been shown to possess both neuroprotective and anti-proliferative properties. Researchers investigated the role of D609 in reducing the proliferation of neural progenitor cells in vitro. [Mol Neurobiol] Abstract

Grafted Human Neural Stem Cells Enhance Several Steps of Endogenous Neurogenesis and Improve Behavioral Recovery after Middle Cerebral Artery Occlusion in Rats
The authors explored whether human fetal striatum-derived neural stem/progenitor cell-grafts influence striatal neurogenesis and promote recovery in stroke-damaged brain. [Neurobiol Dis] Abstract

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)
Wild type and mutated TDP-43 are detected in ubiquitinated forms within the cytosol in several neurodegenerative diseases. Researchers elucidated the mechanisms of TDP-43 interaction with parkin using transgenic A315T mutant TDP-43 mice; lentiviral wild type TDP-43 and parkin gene transfer rat models. [J Biol ChemAbstract | Full Article | Press Release

Webinar: Brent Reynolds on Identification and Characterization of Neural Stem Cells

Neurotrophin Regulation of Neural Circuit Development and Function
The authors summarize some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus is on brain-derived neurotrophic factor, as this is the most widely expressed and studied neurotrophin in the mammalian brain. [Nat Rev Neurosci] Abstract

Biogen Idec Forms First-of-Its-Kind Research Consortium to Identify ALS Drug Targets
Biogen Idec announced that it has created a new research consortium in collaboration with several leading academic research centers that will leverage a range of scientific techniques and disciplines to identify new approaches to treating amyotrophic lateral sclerosis (ALS). [Biogen Idec] Press Release

Amarantus BioScience Acquires Neurodegenerative Diagnostic Intellectual Property Portfolio from Power3 Medical Products

Amarantus BioScience, Inc. announced the company has purchased all of the intellectual property assets from Power3 Medical Products. As part of the transaction, Amarantus took ownership of 20 pending patent applications covering a variety of biomarkers and assays related to the treatment of various diseases including Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis, as well as patent applications related to breast cancer, neuromuscular disease and chronic myelogenous leukemia. [Amarantus BioScience, Inc.] Press Release


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NEW New Avenues for Brain Repair: Programming and Reprogramming the Central Nervous System
June 10-11, 2013
Cambridge, United States

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Postdoctoral Position – Transcriptional Regulation in Neural Stem Cells (Washington University School of Medicine)

Faculty Position – Neural Stem Cell Biology (University of Colorado School of Medicine)

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Postdoctoral Position – Neural Stem Cells and Neurodevelopment (University of Wisconsin – Madison)

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