Volume 6.34 | Aug 29

Neural Cell News 6.34 August 29, 2012
     In this issue: Publications | ReviewsScience News | Industry News | Policy News | Events | Jobs
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TOP STORY
K-ATP Channels in Dopamine Substantia Nigra Neurons Control Bursting and Novelty-Induced Exploration
Researchers found that in medial dopamine neurons of the substantia nigra, the activity of ATP-sensitive potassium (K-ATP) channels enabled NMDA-mediated bursting in vitro as well as spontaneous in vivo burst firing in anesthetized mice. [Nat Neurosci] Abstract

Open Access JoVE Protocol: Discriminating NSCs from NPCs with the NeuroCult™ NCFC Assay
PUBLICATIONS (Ranked by impact factor of the journal)

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo
Scientists found that expression of human tau results in elongation of mitochondria in both Drosophila and mouse neurons. Researchers demonstrated a conserved role for actin and myosin in regulating mitochondrial fission and showed that excess actin stabilization inhibits association of the fission protein DRP1 with mitochondria, leading to mitochondrial elongation and subsequent neurotoxicity. [Neuron]
Abstract | Press Release

Mitofusin 2 Is Necessary for Striatal Axonal Projections of Midbrain Dopamine Neurons
Investigators addressed the importance of mitofusin 1 (Mfn1) and Mfn2 in midbrain dopamine (DA) neurons in vivo by characterizing mice with DA neuron-specific knockout of Mfn1 or Mfn2. [Hum Mol Genet]
Full Article

Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cell Behavior
Researchers developed a feasible and reliable stretching platform combined with photolithography and microfluidic techniques to investigate the effect of directional tensile force and guiding microchannels on neural stem cell behavior. [Nanomedicine] Abstract

Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle and Lower Part of the Vibrissa Hair Follicle
Scientists demonstrated that multipotent, nestin-expressing stem cells are present throughout the hair follicle and that the upper part of the follicle can produce stem cells in large amounts that could be used for nerve and spinal cord repair. [Cell Cycle] Abstract

Inherited Effects of Low-Dose Exposure to Methylmercury in Neural Stem Cells
Scientists investigated short-term direct and long-term inherited effects of exposure to methylmercury using primary cultures of rat embryonic cortical neural stem cells. [Toxicol Sci] Abstract

Regulation of Axonal Growth and Neuromuscular Junction Formation by Neuronal PTEN Signaling
Researchers report a novel function of presynaptic signaling by PTEN (phosphatase and tensin homolog) in mediating a growth-to-synaptogenesis transition in neurons. [Mol Biol Cell] Abstract

Activin A Promotes Neuronal Differentiation of Cerebrocortical Neural Progenitor Cells
Investigators studied if Activin A influences proliferation, differentiation or survival in rat cerebrocortical neural progenitor cells. [PLoS One] Full Article

Ethanol Disrupts Axon Outgrowth Stimulated by Netrin-1, GDNF, and L1 by Blocking their Convergent Activation of Src Family Kinase Signaling
Researchers investigated whether ethanol inhibits the stimulation of axon outgrowth by diverse axon guidance molecules through a common action on the Src family kinases. [J Neurochem] Abstract

BDNF Increases the Motility of a Particular N-Methyl D-aspartate/γ-Amino-Butyric Acid-Responsive Subset of Neural Progenitor Cells
Scientists studied the effect of brain-derived neurotrophic factor (BDNF) on parameters such as motility and neurotransmitter responsiveness of migrating neural progenitors. [Neuroscience] Abstract

Webinar: Brent Reynolds on Identification and Caracterization of Neural Stem Cells

NEW! REVIEWS
Based on your feedback, we’ve added a Reviews section to Neural Cell News

Gene Expression Profiling in Human Neurodegenerative Disease
This review summarizes microarray human gene expression profiling studies in the common neurodegenerative diseases amyotrophic lateral sclerosis, Parkinson disease and Alzheimer disease. [Nat Rev Neurol] Abstract

Contribution of SDF-1α/CXCR4 Signaling to Brain Development and Glioma Progression
This review highlights current knowledge about multiple molecular signaling pathways associated with the SDF-1α/CXCR4 signaling in glioma. [Neurosignals] Abstract

SCIENCE NEWS
Prana Provides Clinical Trials Update
Prana Biotechnology reported on its progress in its phase II clinical trials with its lead development asset PBT2. [Prana Biotechnology] Press Release
INDUSTRY NEWS

Neuralstem Completes Phase I ALS Stem Cell Trial
Neuralstem, Inc. announced the completion of the phase I trial of its NSI-566 spinal cord neural stem cells for the treatment of amyotrophic lateral sclerosis (ALS), with the eighteenth patient treated. [Neuralstem, Inc.] Press Release

Eli Lilly and Company Announces Top-Line Results on Solanezumab Phase III Clinical Trials in Patients with Alzheimer’s Disease
Eli Lilly and Company announced that the primary endpoints, both cognitive and functional, were not met in either of the two phase III, double-blind, placebo-controlled solanezumab EXPEDITION trials in patients with mild-to-moderate Alzheimer’s disease. [Eli Lilly and Company] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW Basic and Clinical Neuroscience Congress
November 7-9, 2012
Tehran, Iran

Visit our events page to see a complete list of events in the neural cell community.

JOB OPPORTUNITIES

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

                                                       

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)


Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Senior Research Associate – Neural Stem Cell (University College London)


Postdoctoral Position – Genetics of Zebrafish Neural Circuits (Uni Research AS, Sars Centre)


Postdoctoral Position – Adult Neural Stem Cell Research (Cleveland Clinic)


Postdoctoral Position – Cell Polarity and Signaling (Mount Sinai School of Medicine)

Postdoctoral Position – Neuroscience (Royal Netherlands Academy for Arts and Science)


Postdoctoral Position – Neural Stem Cell (University of Wisconsin)


Postdoctoral Position – Spinal Cord Neural Stem Cells (INSERM U1051)

Research Associate – Quality Assurance (University of California)



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