Volume 6.14 | Apr 11

Neural Cell News 6.14, April 11, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Small Molecules Enable Highly Efficient Neuronal Conversion of Human Fibroblasts
Scientists present a minimalist approach combining two-factor neuronal programming with small molecule-based inhibition of glycogen synthase kinase-3ß and SMAD signaling, which converts postnatal human fibroblasts into functional neuron-like cells with yields up to >200% and neuronal purities up to >80%. [Nat Methods]
Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

MicroRNA-9 Regulates Axon Extension and Branching by Targeting Map1b in Mouse Cortical Neurons
Researchers found that microRNA-9 controlled axonal extension and branching by regulating the levels of Map1b, an important protein for microtubule stability. [Nat Neurosci] Abstract

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations
Scientists showed that AKT3 is the most abundant AKT paralog in the brain during neurogenesis and that phosphorylated AKT is abundant in cortical progenitor cells. [Neuron] Abstract

Neurofibromatosis-Like Phenotype in Drosophila Caused by Lack of Glucosylceramide Extension
Researchers found that loss of the glycosyltransferase glycosyltransferase Egghead affects membrane signaling and activation of phosphatidylinositol 3-kinase signaling in glia of the peripheral nervous system, and suggest that glycosyltransferases may suppress proliferation. [Proc Natl Acad Sci USA]
Abstract

Mitotic Spindle Orientation Can Direct Cell Fate and Bias Notch Activity in Chick Neural Tube
Researchers showed that divisions that separate apical and basal components generate an apical daughter, which becomes a neuron, and a basal daughter, which rapidly re-establishes apico-basal polarity and divides again. [EMBO J] Abstract

The In Vivo Developmental Potential of Porcine Skin-Derived Progenitors (SKPs) and Neural Stem Cells
Researchers investigated the in vivo developmental potential of porcine SKPs and fetal brain-derived neural stem cells by chimera production [Stem Cells Dev]
Abstract

Gene Expression Profile of Adult Human Olfactory Bulb and Embryonic Neural Stem Cell Suggests Distinct Signaling Pathways and Epigenetic Control
Global gene expression profiling was performed using RNA from human embryonic neural stem cells and adult human olfactory bulb-derived neural stem cells to define a gene expression pattern and signaling pathways that are specific for each cell lineage. [PLoS One] Abstract

ApoTransferrin: Dual Role on Adult Subventricular Zone-Derived Neurospheres
Researchers cultured neural stem and progenitor cells from the rat subventricular zone as neurospheres and studied apoTransferrin effects on oligodendroglial specification and maturation. [PLoS One]
Abstract

Pilot Study of Induced Pluripotent Stem-Derived Neural Cells to Examine Biologic Effects of Alcohol on Human Neurons In Vitro
Researchers used new technologies to reprogram human subject-specific tissue into pluripotent cell colonies and generate human neural cultures as a model system to examine the molecular actions of alcohol. [Alcohol Clin Exp Res] Abstract

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INDUSTRY NEWS

Writing the Book of Cancer Knowledge
An academic-industry collaboration is releasing the first results from a new and freely available resource that marries deeply detailed cancer genome data with predictors of drug response, information that could lead to refinements in cancer clinical trials and future treatments. [The Eli and Edythe L. Broad Institute]
Press Release

Canada and Japan Establish New Research Partnership
The Canadian Institutes of Health Research and the Japan Science and Technology Agency recently signed a partnership agreement to fund joint research projects on the epigenetics of stem cells. [Canadian Institutes of Health Research] Press Release

FDA Approves Amyvid™ (Florbetapir F 18 Injection) for Use in Patients Being Evaluated for Alzheimer’s Disease and Other Causes of Cognitive Decline
Amyvid is the first and only radioactive diagnostic agent approved for PET imaging of beta-amyloid neuritic plaques in the living brain. [Eli Lilly and Company] Press Release

The Comprehensive Epilepsy Center at NYU Langone Recognized by the NAEC As a Level 4 Epilepsy Center
NYU Langone Medical Center announced that its Comprehensive Epilepsy Center was recognized by the National Association of Epilepsy Centers (NAEC) as a Level 4 epilepsy center. [NYU Langone Medical Center] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience
July 14-18, 2012
Barcelona, Spain

Visit our events page to see a complete list of events in the neural cell community.

JOB OPPORTUNITIES

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)


Postdoctoral Position in Stem Cell Biology/Neuroscience/Cancer (The Jackson Laboratory)

Postdoctoral Fellow in Epigenetic Regulation of Neural Stem Cells (University of Wisconsin-Madison)


Postdoctoral Position in Neuronal Cell Biology (University of Basel)


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