Volume 6.07 | Feb 22

Neural Cell News 6.07, February 22, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Allotransplanted Neurons Used to Repair Peripheral Nerve Injury Do Not Elicit Overt Immunogenicity
Scientists examined the immunogenicity of their dorsal root ganglion neuron implanted conduits as a potential strategy to overcome transplant rejection. [PLoS One] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Repetitive Motor Learning Induces Coordinated Formation of Clustered Dendritic Spines In Vivo
To investigate whether neighboring synapses are involved in encoding similar memory and how task-specific cortical networks develop during learning, scientists followed apical dendrites of layer five pyramidal neurons in the motor cortex while mice practiced novel forelimb skills. [Nature]
Abstract | Press Release


ATM Kinase Inhibition in Glial Cells Activates the Innate Immune Response and Causes Neurodegeneration in Drosophila
To investigate the mechanistic basis for central nervous system neurodegeneration in the disease ataxia-telangiectasia (A-T), researchers analyzed flies mutant for the causative gene A-T mutated (ATM). [Proc Natl Acad Sci USA] Abstract


Targeting the UPR Transcription Factor XBP1 Protects against Huntington’s Disease through the Regulation of Forkhead Box O1 and Autophagy
Scientists have investigated the functional contribution of endoplasmic reticulum stress to Huntington’s disease by targeting the expression of two main unfolded protein response (UPR) transcription factors, XBP1 and ATF4, in full-length mutant Huntingtin transgenic mice. [Hum Mol Genet] Abstract


Local Dendrodendritic Inhibition Regulates Fast Synaptic Transmission in Visual Thalamus
To gain additional insight into the computational power of presynaptic dendrites, researchers have combined two-photon laser scanning microscopy, glutamate uncaging, and whole-cell electrophysiological recordings to locally activate dendritic terminals and study their inhibitory contribution to rat thalamocortical relay neurons. [J Neurosci] Abstract


Matrix Metalloproteinase9 Regulates Survival of Neurons in Newborn Hippocampus
Scientists show that levels of the matrix metalloproteinase9 decrease and the level of the extracellular matrix protein laminin increases in rat hippocampus during the period of neuronal death. [J Biol Chem] Abstract

A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome
Researchers report the development of Alzheimer’s disease pathologies in cortical neurons generated from human induced pluripotent stem cells derived from patients with Down syndrome. [Sci Transl Med]
Abstract | Press Release


Developmental Regulation of Membrane Excitability in Rat Spinal Lamina I Projection Neurons
Scientists have used in vitro whole-cell patch clamp recordings in rat spinal cord slices to determine whether the intrinsic membrane properties of lamina I projection neurons, as well as their synaptic inputs, are developmentally regulated during the early postnatal period. [J Neurophysiol] Abstract


Intraneuronally Injected Amyloid Beta Inhibits Long-Term Potentiation in Rat Hippocampal Slices
Scientists have investigated the effect on long term potentiation of intracellular injection of amyloid beta into hippocampal pyramidal cells using patch clamp technique. [J Neurophysiol] Abstract

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INDUSTRY NEWS

New York Genome Center Launches Major Initiative with the Feinstein Institute for Medical Research to Sequence Whole Genomes of Alzheimer’s Patients
New York Genome Center, in collaboration with Illumina, announced at the Advances in Genome Biology and Technology annual meeting the initiation of a large-scale whole genome sequencing project with the Feinstein Institute for Medical Research. [New York Genome Center] Press Release


NeuroPhage Receives Michael J. Fox Foundation Funding for Parkinson’s Disease Research
NeuroPhage Pharmaceuticals, Inc. announced that it has been awarded funding by The Michael J. Fox Foundation to conduct pre-clinical research targeting alpha-synuclein, a protein whose clumping is the pathological hallmark of Parkinson’s disease. [NeuroPhage Pharmaceuticals, Inc.] Press Release


American Academy of Neurology Announces 2012 Research Award Winners
Nearly two dozen scientific research awards are being bestowed on researchers around the world this year by the American Academy of Neurology, the world’s largest association of neurologists. [American Academy of Neurology] Press Release

POLICY NEWS

National Institute of Neurological Disorders and Stroke Notice of Closed Meetings (FR Doc No: 2012-3438) [National Institute of Health, United States]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 2012 Till & McCulloch Meetings 
April 30-May 2, 2012 
Montreal, Canada 


NEW International Society for Cellular Therapy (ISCT) 18th Annual Meeting 
June 5-8, 2012 
Seattle, United States 

Visit our events page to see a complete list of events in the neural cell community.

JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientific Marketing Communications Specialist (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)


Research Technologist (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)


Postdoctoral Fellow – Visual Neuroscience (RIKEN Brain Science Institute)

Postdoctoral Fellow – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)


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