Volume 6.02 | Jan 18

Neural Cell News 6.02, January 18, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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Scientists Decipher Mechanism to Prevent Programmed Cell Death of Nerve Cells
An international research team has discovered a novel mechanism to prevent nerve cell death caused by oxygen and glucose deprivation. [Press release from Charité – Universitätsmedizin Berlin discussing online prepublication in the Proceedings of the National Academy of Sciences, USA] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma
Using PDGF- and KRAS-driven murine models of gliomagenesis, researchers show that high Id1 expression identifies tumor cells with high self-renewal capacity, while low Id1 expression identifies tumor cells with proliferative potential but limited self-renewal capacity. [Cancer Cell] Abstract

A Role for mDia, a Rho-Regulated Actin Nucleator, in Tangential Migration of Interneuron Precursors
Investigators examined neuronal migration in mice deficient in mDia1 (also known as Diap1) and mDia3 (also known as Diap2), which encode the Rho-regulated actin nucleators mammalian diaphanous homolog 1 (mDia1) and mDia3. [Nat Neurosci] Abstract

Postsynaptic Density Protein 95 (PSD-95) Is Post-Transcriptionally Repressed during Early Neural Development by Polypyrimidine Tract Binding Protein 1 (PTBP1) and PTBP2
Researchers found that Psd-95 was controlled post-transcriptionally during neural development. [Nat Neurosci] Abstract

Mitochondrial Dysfunction and Purkinje Cell Loss in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)
Scientists have generated an animal model for ARSACS, sacsin knockout mice, that display age-dependent neurodegeneration of cerebellar Purkinje cells. To explore the pathophysiological basis for this observation, researchers examined the cell biological properties of sacsin. [Proc Natl Acad Sci USA]
Abstract | Press Release

Loss of Autophagy in Hypothalamic POMC Neurons Impairs Lipolysis
Researchers show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. [EMBO Rep] Abstract

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids
The objective of this study was to assess the neuroprotective and pro-regenerative potential of ω-3 polyunsaturated fatty acids in peripheral nerve injury. [J Neurosci] Abstract | Press Release

Prenatal NMDA Receptor Antagonism Impaired Proliferation of Neuronal Progenitor, Leading to Fewer Glutamatergic Neurons in the Prefrontal Cortex
Here, investigators report that prenatal N-methyl-D-aspartate (NMDA) receptor antagonism impaired the proliferation of neuronal progenitors, leading to a decrease in the progenitor pool in the ventricular and the subventricular zone. [Neuropsychopharmacology] Abstract

The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells
Researchers’ results suggest that HuR is an important regulator of Musashi1 in glioblastoma and that this regulation has important biological consequences during gliomagenesis. [Mol Cancer Res]
Abstract |
Press Release

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BrainStorm Announces Clinical Data Supporting Safety and Efficacy of NurOwn™ Based on Initial Patient Results
BrainStorm Cell Therapeutics Inc. announced that the data from the initial patients in its amyotrophic lateral sclerosis Phase I/II human clinical trial treated with its NurOwn™ technology did not present any significant side effects and that the NurOwn™ treatment has so far proven to be safe. [BrainStorm Cell Therapeutics Inc.] Press Release

MediciNova and University of Colorado Boulder Collaborate on Potential Novel Therapy for Traumatic Brain Injury
MediciNova, Inc. and the University of Colorado Boulder disclosed a license agreement for the use of ibudilast (MN-166/AV411) for the treatment of post-traumatic brain injury. [MediciNova, Inc.] Press Release

Neuromuscular Disease Expert Robert H. Baloh, MD, PhD, Joins Cedars-Sinai Medical Center to Advance Lou Gehrig’s Disease Research
Robert H. Baloh, MD, PhD, has joined Cedars-Sinai Medical Center to advance the study of amyotrophic lateral sclerosis, muscular dystrophies, spinal muscular atrophies and other poorly understood disorders that start in nerve cells and electrical signaling. [Cedars-Sinai] Press Release

Otsuka Pharmaceutical and UCB Focus Collaboration in the Area of Central Nervous System (CNS) Disorders
Otsuka Pharmaceutical Co., Ltd. and UCB announced that the companies have agreed to focus their collaboration on the therapeutic area of CNS disorders and to discontinue their collaboration in immunology. [Otsuka Pharmaceutical Co., Ltd.] Press Release

InVivo Therapeutics, Geisinger Health System to Conduct Preclinical Study of Injectable Scaffold for Peripheral Nerve Injury For FDA Submission
InVivo Therapeutics Holdings Corp. (InVivo) and Geisinger Health System announced a research collaboration to conduct a preclinical study using InVivo’s injectable biocompatible hydrogel for the treatment of chronic pain caused by peripheral nerve compression. [InVivo Therapeutics Holdings Corp.] Press Release


National Institute of Neurological Disorders and Stroke Exploratory Clinical Trials for Small Business (STTR [R42]) (PAR-12-072) [National Institutes of Health, United States]

National Institute of Neurological Disorders and Stroke Competing Renewal Awards of STTR Phase II Grants (Phase IIB) for Exploratory Clinical Trials (STTR [R42]) (PAR-12-074) [National Institutes of Health, United States]

National Institute of Neurological Disorders and Stroke Competing Renewal Awards of SBIR Phase II Grants (Phase IIB) for Exploratory Clinical Trials (SBIR [R44]) (PAR-12-075) [National Institutes of Health, United States]

National Institute of Neurological Disorders and Stroke Notice of Meeting (FR Doc No: 2012-379)
[National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW Cell Culture World Congress
February 28-March 1, 2012
Munich, Germany

NEW American Society for Neural Therapy and Repair Annual Meeting
April 26-28, 2012
Clearwater Beach, United States

Visit our events page to see a complete list of events in the neural cell community.


Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Fellow – Adult Neurogenesis and Neural Signaling (University of Kentucky)

Postdoctoral Position – Genetic and Epigenetic Regulation of Neural Stem Cells (The University of Texas Southwestern Medical Center)

Postdoctoral Fellow – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

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