Volume 6.00 | Jan 4

Neural Cell News 6.00, January 4, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Ars2 Maintains Neural Stem-Cell Identity through Direct Transcriptional Activation of Sox2
Here scientists report that the zinc finger protein Ars2 (arsenite-resistance protein 2) is expressed by adult neural stem cells (NSCs) from the subventricular zone (SVZ) of mice, and that selective knockdown of Ars2 in cells expressing glial fibrillary acidic protein within the adult SVZ depletes the number of NSCs and their neurogenic capacity. [Nature] Abstract

Neurospheres or Adherent Cultures? NeuroCult™ does both. (Click to view technical data.)
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Encapsulated Therapeutic Stem Cells Implanted in the Tumor Resection Cavity Induce Cell Death in Gliomas
In this study, researchers investigated a new approach to glioblastoma multiforme (GBM) treatment using therapeutic stem cells encapsulated in biodegradable, synthetic extracellular matrix in mouse models of human GBM resection. [Nat Neurosci] Abstract

Chromatin Modification of Notch Targets in Olfactory Receptor Neuron Diversification
Investigators discovered an epigenetic mechanism in which neuron diversity is maximized via locus-specific chromatin modifications that generate context-dependent responses from a single, generally used intracellular signal. [Nat Neurosci] Abstract

Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites
Here, researchers used calcium imaging to record activity at many synapses of hippocampal pyramidal neurons simultaneously to establish the activity patterns in the majority of synapses of an entire cell. [Neuron] Abstract

Human Long Non-Coding RNAs Promote Pluripotency and Neuronal Differentiation by Association with Chromatin Modifiers and Transcription Factors
With a newly developed method, human embryonic stem cells were robustly and efficiently differentiated into neurons, and researchers profiled the expression of thousands of long non-coding RNAs using a custom-designed microarray. [EMBO J] Abstract

Type 1 Ryanodine Receptor Knock-In Mutation Causing Central Core Disease of Skeletal Muscle Also Displays a Neuronal Phenotype
Here researchers demonstrate that the type 1 ryanodine receptor plays a role in voltage-induced Ca2+ release in nerve terminals. [Proc Natl Acad Sci USA] Abstract

D-Amino Acid Oxidase Controls Motoneuron Degeneration through D-Serine
Here, researchers show that genetic inactivation of D-amino acid oxidase (DAO) in mice reduces the number and size of lower motoneurons with axonal degeneration, and that suppressed DAO activity in reactive astrocytes in the reticulospinal tract predominantly contributes to the D-serine increase in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. [Proc Natl Acad Sci USA] Abstract

A Distinct Response to Endogenous DNA Damage in the Development of Nbs1-Deficient Cortical Neurons
In the present study, researchers demonstrate that neuronal disruption of the human nijmegen breakage syndrome gene (NBS) causes microcephaly characterized by the reduction of cerebral cortex and corpus callosum, recapitulating neuronal anomalies in human NBS. [Cell Res] Abstract

Impaired Neural Development in a Zebrafish Model for Lowe Syndrome
Here, researchers describe a zebrafish model for Lowe syndrome using stable and transient suppression of OCRL1 expression. [Hum Mol Genet] Abstract

Implantation Site and Lesion Topology Determine Efficacy of a Human Neural Stem Cell Line in a Rat Model of Chronic Stroke
Magnetic resonance imaging here confirmed stroke damage and allowed the targeted injection of 450,000 human neural stem cells into peri-infarct tissue, rather than the lesion cyst. [Stem Cells]
Abstract | Press Release

Role of DNMT3B in the Regulation of Early Neural and Neural Crest Specifiers
Researchers performed RNAi knockdown of DNMT3B in human embryonic stem cells in order to investigate the mechanistic contribution of DNMT3B to DNA methylation and early neuronal differentiation. [Epigenetics] Abstract

Free Wallchart from Nature Neuroscience: Neural Stem Cells

INDUSTRY NEWS

Scientists Succeed in Making the Spinal Cord Transparent
Scientists have now developed a new method by virtue of which single nerve cells can be both examined in intact tissue and portrayed in all three dimensions. [Max-Planck-Gesellschaft] Press Release

Celldex Initiates a Phase II Study of Rindopepimut in Patients with Recurrent Glioblastoma including Avastin® Naive and Refractory Populations
Celldex Therapeutics, Inc. announced that patient screening has initiated in a Phase II trial of rindopepimut in combination with Avastin® in patients with recurrent epidermal growth factor variant III-positive glioblastoma, called the “ReACT Study.” [Celldex Therapeutics, Inc.] Press Release

Impax Pharmaceuticals Submits New Drug Application for IPX066 in Parkinson’s Disease
Impax Pharmaceuticals announced the submission of Impax’s New Drug Application for IPX066 to the U.S. Food and Drug Administration for the treatment of idiopathic Parkinson’s disease. [Impax Pharmaceuticals] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Australian Neuroscience Society (ANS) 2012
January 29-February 1, 2012
Gold Coast, Australia

Visit our events page to see a complete list of events in the neural cell community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Fellow – Adult Neurogenesis and Neural Signaling (University of Kentucky)

Postdoctoral Position – Genetic and Epigenetic Regulation of Neural Stem Cells (The University of Texas Southwestern Medical Center)

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