Volume 5.47 | Nov 30

Neural Cell News 5.47, November 30, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Neurons Grown from Skin Cells May Hold Clues to Autism
Using cutting-edge “disease-in a-dish” technology, researchers have grown patients’ skin cells into neurons to discover what goes wrong in the brain in Timothy Syndrome. [Press release from the National Institutes of Health discussing online prepublication in Nature Medicine] Press Release | Abstract

Free Wallchart from Nature Neuroscience: Neural Stem Cells
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Researchers propose that glial cells are components of a bone marrow niche and maintain hematopoietic stem cell hibernation by regulating activation of latent TGF-β. [Cell] Abstract

Excitation-Induced Ataxin-3 Aggregation in Neurons from Patients with Machado-Joseph Disease
Here researchers show that L-glutamate-induced excitation of patient-specific induced pluripotent stem cell-derived neurons initiates Ca2+-dependent proteolysis of ataxin 3 followed by the formation of SDS-insoluble aggregates. [Nature] Abstract | Press Release

Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice
Researchers found that donor neurons differentiated and integrated as four distinct hypothalamic neuron subtypes, formed functional excitatory and inhibitory synapses, partially restored leptin responsiveness, and ameliorated hyperglycemia and obesity in postnatal leptin receptor-deficient (db/db) mice. [Science]
Abstract | Press Release

Optical Recording of Action Potentials in Mammalian Neurons Using a Microbial Rhodopsin
Reliable optical detection of single action potentials in mammalian neurons has been one of the longest-standing challenges in neuroscience. Here investigators achieved this goal by using the endogenous fluorescence of a microbial rhodopsin protein, Archaerhodopsin 3 from Halorubrum sodomense, expressed in cultured rat hippocampal neurons. [Nat Methods] Abstract

Coordinated Regulation of Cholinergic Motor Neuron Traits through a Conserved Terminal Selector Gene
Researchers show here that, in the nematode Caenorhabditis elegans, all members of the cholinergic gene battery, as well as many other markers of terminal motor neuron fate, are co-regulated by a shared cis-regulatory signature and a common trans-acting factor, the phylogenetically conserved COE (Collier, Olf, EBF)-type transcription factor UNC-3. [Nat Neurosci] Abstract

SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation
Scientists report a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1 (NF1). [Dev Cell] Abstract

Wiring Economy and Volume Exclusion Determine Neuronal Placement in the Drosophila Brain
Here researchers tested whether wiring economy together with volume exclusion can explain the placement of neurons in a module of the Drosophila melanogaster brain known as lamina cartridge. [Curr Biol] Abstract

Significance of Remyelination by Neural Stem/Progenitor Cells Transplanted into the Injured Spinal Cord
Oligodendrocytes derived from grafted neural stem/progenitor cells remyelinate spared axons in the injured spinal cord. Here, researchers studied the extent of this remyelination’s contribution to functional recovery following contusive spinal cord injury in mice. [Stem Cells] Abstract

Striatal Dysfunctions Associated with Mitochondrial DNA Damage in Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
Researchers used a mouse model expressing a mitochondria-targeted restriction enzyme, PstI or mito-PstI, to damage mitochondrial DNA in dopaminergic neurons. [J Neurosci] Abstract

Ubiquitin Homeostasis Is Critical for Synaptic Development and Function
Here, researchers show that transgenic complementation of ataxia (axJ) mice with neuronally expressed ubiquitin prevents early postnatal lethality, restores muscle mass, and corrects developmental and functional deficits resulting from the loss of Usp14, demonstrating that ubiquitin deficiency is a major cause of the neurological defects observed in the axJ mice. [J Neurosci] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response

INDUSTRY NEWS

Dr. Andrew B. Lassman Named Chief of Neuro-Oncology at NewYork-Presbyterian Hospital/Columbia University Medical Center
Dr. Andrew B. Lassman has joined the Neurological Institute at NewYork-Presbyterian Hospital/Columbia University Medical Center as chief of neuro-oncology, a new program focusing on caring for patients with brain tumors and metastases as well as research into new treatments. [NewYork-Presbyterian Hospital]
Press Release

Cambridge-Elan Centre for Research Innovation and Drug Discovery Launched
The Cambridge-Elan Centre for Research Innovation and Drug Discovery will provide a highly interdisciplinary environment uniquely positioned for delivering world-leading translational research focused on innovative therapies for Alzheimer’s and Parkinson’s diseases. [Elan Corporation, plc.] Press Release

Civitas Therapeutics Announces Award of Michael J. Fox Foundation Grant and Lead Drug Candidate for Parkinson’s Disease
The grant from The Michael J. Fox Foundation for Parkinson’s Research will support the clinical development of CVT-301, which has the potential to produce rapid, consistent and durable relief from debilitating motor fluctuations associated with Parkinson’s disease. [Civitas Therapeutics, Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Keystone Symposia on Molecular and Cellular Biology: The Life of a Stem Cell: From Birth to Death
March 11-16, 2012
Olympic Valley, United States

Visit our events page to see a complete list of events in the neural cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)               

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 


Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Lab Technologist Position (Michigan State University)

Postdoctoral Position – Neuronal Stem Cell Research (University of Connecticut Health Center)

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