Volume 5.32 | Aug 17

Neural Cell News 5.32, August 17, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Human-Cell-Derived Model of ALS Provides a New Way to Study the Majority of Cases
In a new study, investigators have developed a new model of amyotrophic lateral sclerosis (ALS), one that mimics sporadic ALS. [Press release from Nationwide Children’s Hospital discussing online prepublication in Nature Biotechnology]

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SCIENCE NEWS

Study Finds Enzyme Disrupting Nerve Cell Communication in Alzheimer’s Disease
A research team found that the altered form of Cdk5 (SNO-Cdk5) was prevalent in human Alzheimer’s disease brains, but not in normal brains. [Press release from Sanford-Burnham Medical Research Institute discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

Holograms Reveal Brain’s Inner Workings: Microscopy Technique Used to Observe Activity of Neurons Like Never Before
A team of neurobiologists, psychiatrists, and advanced imaging specialists report how Digital Holographic Microscopy can now be used to observe neuronal activity in real-time and in three dimensions—with up to 50 times greater resolution than ever before. [Press release from the École Polytechnique Fédérale de Lausanne discussing online prepublication in the Journal of Neuroscience]

New Research Reveals Brain’s Natural Protection Mechanism During Stroke
Neuroscientists have identified a natural protection mechanism in some of the brain’s nerve cells during the onset of stroke. [Press release from the University of Bristol discussing online prepublication in the Journal of Neuroscience]

Graphene Is the Brainy Choice for Stem-Cell Growth
Neural stem cells grown on graphene have a greater ratio of neurons to glial cells than when grown on glass, according to researchers. [Press release from Materials Views discussing online prepublication in Advanced Materials]

A Mold on Which to Create New Parts of the Puzzle That Is the Nervous System
A researcher has developed a polymer material which contains topographic and biochemical characteristics suitable for converting cells into functional neurons. [Basque Research Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Nicotinic Acetylcholine Receptor β2 Subunits in the Medial Prefrontal Cortex Control Attention
Efficient lentiviral vector–mediated reexpression of functional β2-subunit–containing nicotinic acetylcholine receptors in prefrontal cortex neurons of the prelimbic area completely restored the attentional deficit but did not affect impulsive and motivational behavior. [Science]

Astrocytes from Familial and Sporadic ALS Patients Are Toxic to Motor Neurons
Using astrocytes generated from postmortem tissue from both familial amyotrophic lateral sclerosis (ALS) and sporadic ALS patients, researchers show that astrocytes derived from both patient groups are similarly toxic to motor neurons. [Nat Biotechnol]

Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease
Here, investigators showed that intravenous administration of neural progenitor cells ameliorated experimental autoimmune encephalomyelitis by selectively inhibiting pathogenic T helper 17 cell differentiation. [Immunity]

Role of Rodent Secondary Motor Cortex in Value-Based Action Selection
Here researchers examined neuronal activity in the lateral and medial agranular cortex, corresponding to the primary and secondary motor cortex, respectively, in rats performing a dynamic foraging task. [Nat Neurosci]

Enhanced Differentiation of Human Neural Stem Cells into Neurons on Graphene
Graphene-substrate-promoted human neural stem cell adhesion and its differentiation into neurons is reported. [Adv Mater]

S-Nitrosylation Activates Cdk5 and Contributes to Synaptic Spine Loss Induced by ß-Amyloid Peptide
Researchers show that S-nitrosylation of Cdk5 contributes to amyloid-β peptide-induced dendritic spine loss. [Proc Natl Acad Sci USA]

Magnetically Enhanced Adeno-Associated Viral Vector Delivery for Human Neural Stem Cell Infection
In this study, researchers developed a magnetically guided adeno-associated virus delivery system for gene delivery to human neural stem cells. [Biomaterials]

ADAM17/TACE Inhibits Neurogenesis and Promotes Gliogenesis from Neural Stem Cells
These results indicate that, in vivo, the activation of a metalloprotease, most probably ADAM-17, initiates EGFR-ligand shedding and EGFR activation in an autocrine manner, preventing the generation of new neurons from neural precursor cells. [Stem Cells]

Oxygen/Glucose Deprivation Induces a Reduction in Synaptic AMPA Receptors on Hippocampal CA3 Neurons Mediated by mGluR1 and Adenosine A3 Receptors
Here, researchers investigated the consequences of oxygen/glucose deprivation for AMPA receptor function in CA3 neurons using electrophysiological recordings in rat hippocampal slices. [J Neurosci]

Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Cotransporters KCC2 and NKCC1: A Digital Holographic Microscopy Study
Here, researchers show that glutamate produces the following three distinct optical responses in mouse primary cortical neurons in culture, predominantly mediated by NMDA receptors: biphasic, reversible decrease and irreversible decrease responses. [J Neurosci]

INDUSTRY NEWS

Impax and GSK Announce Positive Topline Results of ASCEND-PD Phase III Study of IPX066 in Advanced Parkinson’s Disease
Impax Pharmaceuticals and GlaxoSmithKline (GSK) announced top-line results of the ASCEND-PD Phase III clinical study of IPX066 versus carbidopa-levodopa plus entacapone, in patients with advanced Parkinson’s disease. [Impax Laboratories, Inc. Press Release]

Neuralstem Reports Second Quarter Financial Results and Provides Business and Clinical Update
Neuralstem, Inc. reported its financial results for the three months and six months period ended June 30, 2011 and provided a business and clinical update. [Neuralstem, Inc. Press Release]

Neurologix Announces Second Quarter 2011 Financial Results
Neurologix, Inc. announced its financial results for the three and six months ended June 30, 2011. [Neurologix, Inc. Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC ’11)
August 30 – September 3, 2011
Boston, United States

Visit our
events page
to see a complete list of events in the neural cell community.
JOB OPPORTUNITIES

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Research and Development Technologist (STEMCELL Technologies) 


Information Management Scientist – Scientific Data Management (Databases) (Dart Neuroscience LLC)

Postdoctoral Position (University of California, Davis)


Postdoctoral Researchers (University of Cambridge)

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