Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Microglial Over-Pruning of Synapses during Development in Autism-Associated SCN2A-Deficient Mice and Human Cerebral Organoids

[Molecular Psychiatry] Scientists reported that Scn2a-deficient mice had impaired learning and memory, accompanied by reduced synaptic transmission and lower spine density in neurons of the hippocampus.

Interactions Between Cancer Cells and Immune Cells Drive Transitions to Mesenchymal-Like States in Glioblastoma

[Cancer Cell] Investigators dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.

SRF Transcriptionally Regulates the Oligodendrocyte Cytoskeleton during CNS Myelination

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that serum response factor (SRF) was required cell autonomously in oligodendrocytes for myelination during development.

Updates on Mouse Models of Alzheimer’s Disease

[Molecular Neurodegeneration] Scientists summarize the phenotypes of commonly used as well as newly developed mouse models in translational research laboratories including the presence or absence of key pathological features of Alzheimer's disease.

APOE4/4 Is Linked to Damaging Lipid Droplets in Alzheimer’s Disease Microglia

[Nature] Through single-nucleus RNA sequencing of brain tissue in Alzheimer’s disease, researchers have identified a microglial state defined by the expression of the lipid droplet-associated enzyme ACSL1 with ACSL1-positive microglia being most abundant in patients with Alzheimer’s disease having the APOE4/4 genotype.

Mitochondrial Complex I Activity in Microglia Sustains Neuroinflammation

[Nature] Using a multiomics approach, the authors identified a molecular signature that sustained the activation of microglia through mitochondrial complex I activity driving reverse electron transport and the production of reactive oxygen species.

Neuronal STING Activation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

[Acta Neuropathologica] document neuronal activation of the stimulator of interferon genes (STING) pathway in human postmortem cortical and spinal motor neurons from individuals affected by familial or sporadic amyotrophic lateral sclerosis.

Neuropathogenesis-on-Chips for Neurodegenerative Diseases

[Nature Communications] The authors explore the interconnected pathogenic features of different types of neurodegenerative disease (ND), discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model.

Hydrogen Sulfide Improves Endothelial Barrier Function by Modulating the Ubiquitination Degradation of KLF4 Through TRAF7 S-sulfhydration in Diabetic Aorta

[Free Radical Biology And Medicine] The authors investigated whether protein S-sulfhydration in the endothelium regulates endothelial integrity and its underlying mechanism.

Single Neurons in the Thalamus and Subthalamic Nucleus Process Cardiac and Respiratory Signals in Humans

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researcher investigated the activity of single neurons related to cardiac and respiratory functions in three subcortical regions: ventral intermedius nucleus and ventral caudalis nucleus of the thalamus, and subthalamic nucleus.

Cytosolic DNA Sensors in Neurodegenerative Diseases: From Physiological Defenders to Pathological Culprits

[EMBO Molecular Medicine] The authors summarize profiles of several major cytosolic DNA sensors and their common adaptor protein STING. They also discuss both the beneficial and detrimental roles of cytosolic DNA sensors in the genesis and progression of neurodegenerative diseases.

U of T Startup Targets Harmful Side Effect of Cancer Treatment

[University of Toronto] HDAX Therapeutics is focused on developing treatments for peripheral nerve damage, which can result from chemotherapy or radiation.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.

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