Volume 4.17 | May 5

Neural Cell News 4.17, May 5, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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Neural Stem Cell Transplantation Offers Hope to Children with Rare but Incurable and Fatal Batten Disease
Researchers investigated the transplantation of neural stem cells in patients with advanced stage infantile and late-infantile Neuronal Ceroid Liposfuscinosis. [Press release from Oregon Health & Science University discussing research presented at the 78th Annual Meeting of the American Association of Neurological Surgeons]



New Method Reveals How Individual Nerve Cells Process Visual Input
Pioneering a novel microscopy method, neuroscientists have shown that individual neurons carry out significant aspects of sensory processing: specifically, in this case, determining which direction an object in the field of view is moving. [Press release from Technische Universität München discussing online prepublication in Nature]

Treating Battlefield Injuries with Light-Activated Technology
This new treatment for war injuries includes using a process or technology called Photochemical Tissue Bonding, which can replace conventional sutures, staples and glues in repairing skin wounds, reconnecting severed peripheral nerves, blood vessels, tendons and incisions in the cornea. [Air Force Office of Scientific Research Press Release]



Dendritic Organization of Sensory Input to Cortical Neurons In Vivo
Researchers report a novel approach for the visualization and functional mapping of sensory inputs to the dendrites of cortical neurons in vivo. [Nature]

Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning
Investigators demonstrate in mouse motor cortex slices that direct current stimulation (DCS) induces a long-lasting synaptic potentiation, which is polarity specific, NMDA receptor dependent, and requires coupling of DCS with repetitive low-frequency synaptic activation. [Neuron]

Induction and Regulation of Differentiation in Neural Stem Cells on Ultra-Nanocrystalline Diamond Film
This study demonstrated that hydrogen-terminated ultra-nanocrystalline diamond films-mediated neural stem cells differentiation involves fibronectin-integrin beta1 and Fak-MAPK/Erk signaling pathways in the absence of differentiation factors. [Biomaterials

Human Embryonic Stem Cell-Derived Neurons as a Tool for Studying Neuroprotection and Neurodegeneration
Far from replacing rodent in vivo and primary culture systems, human embryonic stem and induced disease-specific pluripotent stem cell-derived neurons offer a complementary resource to overcome issues of interspecies differences, accelerate drug discovery, study of disease mechanism and provide basic insight into human neuronal physiology. [Mol Neurobiol]

The Signals of FGFs on the Neurogenesis of Embryonic Stem Cells
By using a serum-free neural induction method, researchers showed that FGF1 dose-dependently promoted the induction of Sox1/N-cadherin/nestin triple positive cells, which represent primitive neuroblasts, from mouse embryonic stem cells. [J Biomed Sci]

Proliferation and Differentiation of Neural Stem Cells Are Selectively Regulated by Knockout of Cyclin D1
Researchers investigated the effect of the inhibition of cell cycle by cyclin D1 gene knockout on proliferation and differentiation of neural stem cells. [J Mol Neurosci]

Osteogenic and Neurogenic Differentiation of EGFP Gene Transfected Neural Stem Cells Derived from the Brain of Porcine Fetuses at Intermediate and Late Gestational Age
The aims of this study were to determine whether neural stem cells could be isolated from the brain of porcine fetuses at intermediate and late gestational age, and to determine if these stem cells could be differentiated in vitro into osteogenic and neurogenic lineages following transfection with a reporter gene, enhanced green fluorescence protein. [Cell Biol Int]

Co-Graft of Allogeneic Immune Regulatory Neural Stem Cells and Pancreatic Islets Mediates Tolerance, While Inducing NPC-Derived Tumors in Mice
The aim of this study was to define whether neural stem/precursor cells (NPC) administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model. [PLoS One]


New Positive Data Regarding ReNeuron’s Stem Cell Line for Stroke to be Presented at U.S. Conference
ReNeuron Group plc announces that positive data from a number of new pre-clinical studies using its CTX stem cell line for stroke will be presented in an oral presentation and posters at the 17th Annual Conference of the American Society for Neural Therapy and Repair. [ReNeuron Group plc Press Release]

BrainCells Issued First U.S. Patent for Drug Combinations That Modulate Neurogenesis
BrainCells Inc. announced that the United States Patent and Trademark Office issued the company Patent Number 7,678,808 entitled, “5 HT Receptor Mediated Neurogenesis.” [BrainCells Inc. Press Release]

Mesoblast Completes Enrolment for First Spinal Fusion Trial
Mesoblast’s first trial evaluating its proprietary allogeneic, or “off-the-shelf”, stem cells for posterolateral lumbar spinal fusion, at New York’s Hospital for Special Surgery, has now completed enrolment, and has been fully reviewed by the Data Safety and Monitoring Board. [Mesoblast Limited Press Release]

McKnight Brain Institute Researchers Receive $250,000 to Study Cell-Based Epilepsy Treatment
University of Florida researchers will receive $250,000 to study an inventive cell-transfer therapy to treat cortical dysplasia, a condition where the brain develops abnormally before birth, causing severe epilepsy in children and adults. [University of Florida Health Science Center Press Release]

The New York Stem Cell Foundation and the Johns Hopkins University School of Medicine to Collaborate on Stem Cell Research
The Johns Hopkins University School of Medicine and The New York Stem Cell Foundation are establishing a collaborative program to advance the development and use of stem cells in therapies for a wide range of diseases. [The New York Stem Cell Foundation Press Release]

Vitro Forms Strategic Alliance With a Leading Stem Cell Company
Vitro Diagnostics, Inc., dba Vitro Biopharma, announced that it signed a contract to jointly manufacture and distribute stem cell analysis tools with HemoGenix®, Inc. [Marketwire]

In Montgomery County, Plans for Bioscience Development Nears Approval
Plans for a “science city” in Montgomery County are expected to win approval from the County Council, a move that officials hope will lead to the creation of a $10 billion, 17.5 million-square-foot center for research and development. [Washington Post]


Collins Tells Congress NIH Budget Will Pay Off
National Institutes of Health Director Francis Collins went to Capitol Hill to express his support for President Barack Obama’s proposed 2011 budget for the institutes. [National Institutes of Health, United States]

Science Panel Cuts Authorization Levels for Three COMPETES Agencies
The House of Representatives Science and Technology Committee scaled back proposed funding levels for three key science agencies as part of its reauthorization of the America COMPETES Act. [The House of Representatives Science and Technology Committee, United States]

Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants
The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commission, European Union]

$11.5 Million for Stem Cell Therapy Research
Ontario’s provincial government has announced $11.5 million in funding support for researchers at McMaster University, who are developing stem cell-based therapies. [Global Leadership Round in Genomics & Life Sciences, Canada]

CIRM Awards $28 Million to Answer Fundamental Questions in Stem Cell Biology
At a meeting at the City of Hope, the governing board of the California Institute for Regenerative Medicine (CIRM), the state stem cell agency created by Proposition 71, approved funding $28 million to support 16 Basic Biology II Awards that answer fundamental questions about stem cell biology and one Leadership Award. [California Institute for Regenerative Medicine, United States]

Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092) [National Institutes of Health, United States]

Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 (NOT-AR-10-035) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States]

Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States]

List of Establishments Granted Approval for a Variance to 21CFR640.3(d) and 21CFR640.3(f) [Center for Biologics Evaluation and Research, United States]

May 7, 2010: Vaccines and Related Biological Products Advisory Committee Meeting Announcement [Center for Biologics Evaluation and Research, United States]

Considerations Regarding Food and Drug Administration Review and Regulation of Articles for the Treatment of Rare Diseases; Public Hearing [Docket No. FDA-2010-N-0218] [Food and Drug Administration, United States]


2010 Canadian Neuroscience Meeting
May 15-18, 2010
Ottawa, Canada

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

BIT’s 1st World Congress of NeuroTalk 2010
June 25-28, 2010
Singapore City, Singapore

7th Federation of European Neuroscience Societies (FENS) Forum of European Neuroscience
July 3-7, 2010
Amsterdam, The Netherlands

6th International Symposium on Neuroprotection and Neurorepair
October 1-4, 2010
Rostock, Germany

40th Annual Meeting of the Society for Neuroscience 2010
November 13-17, 2010
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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