Volume 4.15 | Apr 21

Neural Cell News 4.15, April 21, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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Neurons Growing in Line
A group of scientists has successfully developed a novel method to grow cultured neurons in order to investigate basic mechanisms of memory. [Press release from EurekAlert! discussing online prepublication in Neuron]



Gene Links Neurodegeneration and Cancer
In work that could lead to new insights into how neurons protect against neurodegeneration, researchers report that a gene family known for its role in controlling cell proliferation and suppressing tumors is also essential in the brain to regulate neuronal structure and function. [Press release from Massachusetts Institute of Technology discussing online prepublication in the Journal of Neuroscience]

Stem Cells from Menstrual Blood May Benefit Stroke Patients
Cryo-Cell International, Inc. announced results of a study showing that stem cells found in menstrual blood may one day be a potential source for stem cell therapies in stroke and other central nervous system disorders. [Press release from Cryo-Cell International, Inc. discussing online prepublication in Stem Cells and Development]

Cell Transplants May Benefit Children with Cerebral Palsy
A unique cell type that supports and surrounds neurons within the nose known as olfactory ensheathing cells, possess the ability to regenerate, are relatively easy to obtain, and have become prime candidates for transplantation to repair a number of lesions in the central nervous system. [Press release from EurekAlert! discussing online prepublication in Cell Transplantation]

Study Identifies Small Molecules Mimicking Key Brain Growth Factor
Researchers have identified several small molecules that mimic a key but cumbersome protein in the brain, a discovery that could open the door to new therapies for a variety of brain disorders. [Press release from Stanford University School of Medicine discussing online prepublication in the Journal of Clinical Investigation]



Small Molecule BDNF Mimetics Activate TrkB Signaling and Prevent Neuronal Degeneration in Rodents
Using in silico screening with a brain-derived neurotrophic factor (BDNF) loop–domain pharmacophore, followed by low-throughput in vitro screening in mouse fetal hippocampal neurons, researchers have efficiently identified small molecules with nanomolar neurotrophic activity specific to tropomyosin-related kinase B (TrkB) versus other Trk family members. [J Clin Invest]

Microfluidic Local Perfusion Chambers for the Visualization and Manipulation of Synapses
Researchers developed a microfluidic local perfusion chamber to access and manipulate synaptic regions and presynaptic and postsynaptic compartments in vitro. [Neuron]

Esophageal Cancer-Related Gene 4 is a Secreted Inducer of Cell Senescence Expressed by Aged CNS Precursor Cells
Using a serum-induced mouse oligodendrocyte precursor cell senescence model, researchers identified esophageal cancer-related gene 4 as a senescence inducer with implications for the senescence-like state of postmitotic cells in the aging brain. [Proc Natl Acad Sci U S A]

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells
In this study, researchers investigated whether fragile X mental retardation protein deficiency affects adult neurogenesis. [PLoS Genet]

DMob4/Phocein Regulates Synapse Formation, Axonal Transport, and Microtubule Organization
To further characterize the Drosophila Phocein homolog, researchers generated null and hypomorphic alleles and performed in vivo cell biological and physiological analysis. [J Neurosci]

Intracranial Transplant of Olfactory Ensheathing Cells in Children and Adolescents With Cerebral Palsy: A Randomized Controlled Clinical Trial
To elucidate the feasibility of using olfactory ensheathing cells to treat cerebral palsy in children and adolescents, researchers conducted a randomized controlled clinical trial on 33 patients. [Cell Transplant]

Immunohistochemical Expression of Stem Cell, Endothelial Cell, and Chemosensitivity Markers in Primary Glioma Spheroids Cultured in Serum-Containing and Serum-Free Medium
In this first study of the influence of serum-free medium on primary glioma spheroids, the conditions favored an in vivo-like phenotype with increased expression of CD133. [Neurosurgery]

Menstrual Blood Cells Display Stem Cell-Like Phenotypic Markers and Exert Neuroprotection Following Transplantation in Experimental Stroke
In order to test the therapeutic potential of menstrual blood autologous stem cells, researchers used the in vitro stroke model of oxygen glucose deprivation (OGD) and found that OGD-exposed primary rat neurons that were co-cultured with menstrual blood-derived stem cells or exposed to the media collected from cultured menstrual blood exhibited significantly reduced cell death. [Stem Cells Dev]


Cegedim Dendrite and UCB Sign Global Software as a Service CRM Agreement
Cegedim Dendrite has signed a global software as a service CRM agreement with biopharmaceutical company UCB. [Cegedim Dendrite Press Release]

Florida Biotech Research Money in Jeopardy
Florida researchers could lose $50 million in biomedical research funding due to the state’s $3 billion budget deficit. [Orlando Business Journal]

Quebec Biotechs in Tailspin
Once Canada’s envy, and in the same league as Boston and San Francisco, Quebec’s biotechnology industry is a shadow of its former self and in danger of disappearing, observers say. [The Gazette]


Stem Cell Funding in Sight
Two of the most widely used embryonic stem cell lines could be just weeks away from being eligible for United States federal funding. [Obama Administration, United States]

Obama Picks Pragmatists for New Bioethics Panel
President Barack Obama named the members of his bioethics commission — headed by two university presidents. [National Bioethics Commission, United States]

Policy Reminder Concerning Appendix Materials for All National Institutes of Health/Agency for Healthcare Research and Quality/National Institute for Occupational Safety and Health Grant Applications (NOT-OD-10-077) [National Institutes of Health, United States]

Enhancing Peer Review: Clarification of Resubmission Policy and Determination of New Application Status (NOT-OD-10-080) [National Institutes of Health, United States]

Guidance on Confirming Appropriate Charges to NIH Awards during Periods of Noncompliance for Activities Involving Animals (NOT-OD-10-081) [National Institutes of Health, United States]

Update of Sample Animal Welfare Assurance for Foreign Institutions (NOT-OD-10-083) [National Institutes of Health, United States]

Agency for Healthcare Research and Quality Small Research Grant Program (R03) (PAR-10-168) [National Institutes of Health, United States]

Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P) List of Registered Establishments [Center for Biologics Evaluation and Research, United States]

Preparation for International Conference on Harmonisation Steering Committee and Expert Working Group Meetings in Tallinn, Estonia; Regional Public Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]


17th Annual Conference of the American Society for Neural Therapy & Repair (ASNTR)
April 29-May 1, 2010
Clearwater Beach, United States

European Symposium on Stem Cell Research for Stroke
May 4-5, 2010
Ascotel, France

2010 Canadian Neuroscience Meeting
May 15-18, 2010
Ottawa, Canada

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

BIT’s 1st World Congress of NeuroTalk 2010
June 25-28, 2010
Singapore City, Singapore

7th Federation of European Neuroscience Societies (FENS) Forum of European Neuroscience
July 3-7, 2010
Amsterdam, The Netherlands

6th International Symposium on Neuroprotection and Neurorepair
October 1-4, 2010
Rostock, Germany

40th Annual Meeting of the Society for Neuroscience 2010
November 13-17, 2010
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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