Volume 4.14 | Apr 14

Neural Cell News 4.14, April 14, 2010
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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Faulty Cleanup Process May Be Key Event in Huntington’s Disease
In a step towards a possible treatment for Huntington’s disease, scientists have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington’s disease. [Press release from Albert Einstein College of Medicine of Yeshiva University discussing online prepublication in Nature Neuroscience]



Sensitive Nerve Cells
Scientists have demonstrated using a new animal model that nerve cells do not begin to die to the extent found in “Parkinson’s” in mice until three conditions come together. [Press release from Max Planck Institute of Neurobiology discussing online prepublication in PLoS Biology]

Brain Tumor-Causing Stem Cells Also Found to Have Role in Severe Epilepsy
Researchers have published a study that identifies a group of abnormal stem cells that contribute to severe epilepsy in children. [University College of London Institute of Child Health Press Release]

Buck Institute Study Suggests New Strategy for Treatment of Stroke
A study in rodents shows the growth of new neurons, lessens the severity of stroke and dramatically improves function following a stroke. [Press release from Buck Institute for Age Research discussing online prepublication in Proceedings of the National Academy of Sciences USA]



Cargo Recognition Failure is Responsible for Inefficient Autophagy in Huntington’s Disease
Researchers propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside Huntington’s disease cells. [Nat Neurosci]

Pro-Survival Role for Parkinson’s Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons
Investigators uncover a conserved interaction between DJ-1 and Ret-mediated signaling and a novel cell survival role for DJ-1 in the mouse. [PLoS Biol]

Transgenic Ablation of Doublecortin-Expressing Cells Suppresses Adult Neurogenesis and Worsens Stroke Outcome in Mice
Findings provide evidence that injury-induced neurogenesis contributes to stroke outcome and might therefore be a target for stroke therapy. [Proc Natl Acad Sci U S A]

A Nerve Graft Constructed with Xenogeneic Acellular Nerve Matrix and Autologous Adipose-Derived Mesenchymal Stem Cells
Researchers constructed a nerve regeneration characteristics-containing nerve graft through integrating xenogeneic acellular nerve matrix with autologous neural differentiated adipose-derived mesenchymal stem cells. [Biomaterials]

Ectopic Expression of Alpha-Synuclein Affects the Migration of Neural Stem Cells in Mouse Subventricular Zone
Researchers investigated neurosphere formation in vitro and migration of neuronal stem cells (NSC) in vivo after transduction of alphaSyn-encoding retroviral vector to characterize the function of alphaSyn in NSC. [J Neurochem]

Cerebrospinal Fluid Promotes Survival and Astroglial Differentiation of Adult Human Neural Progenitor Cells but Inhibits Proliferation and Neuronal Differentiation
Adult human leptomeningeal cerebrospinal fluid creates a beneficial environment for the survival and differentiation of adult human neural stem cells. [BMC Neurosci]

Proliferation, Migration, and Neuronal Differentiation of the Endogenous Neural Progenitors in Hippocampus After Fimbria Fornix Transection
To determine whether denervation stimulates neurogenesis in hippocampus, proliferation, migration, and differentiation, of local neural stem cells in dentate gyrus was investigated after fimbria fornix transection. [Int J Neurosci]

Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants
Human embryonic stem cells have efficient double-strand break repair that is largely ATR-dependent homologous recombination repair, whereas astrocytes critically depend on ATM for nonhomologous end joining, which, in part, is DNA-PKcs-independent. [PLoS One]


Four Aggies Honored by Goldwater Scholarship Program
Four Texas A&M University sophomores have been honored in a national competition by the Barry M. Goldwater Scholarship and Excellence in Education Program. [Texas A&M Press Release]

Institute Forms Partnership with Group in Tokyo
The Wake Forest Institute for Regenerative Medicine has formed an international partnership that holds promise for accelerating the pace of developing therapies for patients. [Winston-Salem Journal]


University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues
Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States]

National Human Genome Research Institute Names New Chief of Genome Technology Branch
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States]

Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States]

Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States]

Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States]

Clinical Investigator Status (Biologics) [Center for Biologics Evaluation and Research, United States]

Background on Study Results of U.S. Academic Researchers [Center for Biologics Evaluation and Research, United States]

Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Food and Drug Administration, United States]


17th Annual Conference of the American Society for Neural Therapy & Repair (ASNTR)
April 29-May 1, 2010
Clearwater Beach, United States

2010 Canadian Neuroscience Meeting
May 15-18, 2010
Ottawa, Canada

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

BIT’s 1st World Congress of NeuroTalk 2010
June 25-28, 2010
Singapore City, Singapore

7th Federation of European Neuroscience Societies (FENS) Forum of European Neuroscience
July 3-7, 2010
Amsterdam, The Netherlands

40th Annual Meeting of the Society for Neuroscience 2010
November 13-17, 2010
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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