Volume 10.06 | Feb 17

Neural Cell News 10.06 February 17, 2016
Neural Cell News
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Breakable Genes May Promote Disease and Brain Cell Diversity
Researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage. The fragility of those genes could explain why they are often mutated or deleted in cancers and neuropsychiatric disorders such as schizophrenia. [Press release from Howard Hughes Medical Institute discussing online publication in Cell] Press Release | Abstract | Graphical Abstract
PUBLICATIONS (Ranked by impact factor of the journal)
Adult Restoration of Shank3 Expression Rescues Selective Autistic-Like Phenotypes
The authors generated a novel Shank3 conditional knock-in mouse model, and showed that re-expression of the Shank3 gene in adult mice led to improvements in synaptic protein composition, spine density and neural function in the striatum. [Nature] Abstract | Press Release

Neuronal Differentiation Is Associated with a Redox-Regulated Increase of Copper Flow to the Secretory Pathway
Scientists demonstrated that upon neuronal differentiation, cellular demand for copper increases, especially within the secretory pathway. Copper flow to this compartment is facilitated through transcriptional and metabolic regulation. [Nat Commun] Full Article | Press Release

Targeted Axonal Import (TAxI) Peptide Delivers Functional Proteins into Spinal Cord Motor Neurons after Peripheral Administration
Using an in vivo phage-display screen, researchers identified a peptide, targeted axonal import (TAxI), that enriched recombinant bacteriophage accumulation and delivered protein cargo into spinal cord motor neurons after intramuscular injection. [Proc Natl Acad Sci USA] Abstract

The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory
Scientists uncovered a surprising role of the anterograde molecular motor UNC-104/KIF1A as a key regulator of neural circuit deterioration in aging Caenorhabditis elegans. [Curr Biol] Abstract

miRNA-128 Regulates the Proliferation and Neurogenesis of Neural Precursors by Targeting PCM1 in the Developing Cortex
Researchers demonstrated that microRNA (miR)-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1). [eLife] Full Article | Press Release

C. elegans Body Cavity Neurons are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves
Researchers identify Caenorhabditis elegans body cavity neurons called URX(L/R) as central homeostatic sensors that integrate fluctuations in oxygen availability with internal metabolic state. [Cell Rep] Full Article | Press Release | Graphical Abstract

Non-Canonical Features of the Golgi Apparatus in Bipolar Epithelial Neural Stem Cells
Researchers report novel features of the Golgi apparatus, a central organelle for cell polarity, in mouse apical radial glia. [Sci Rep] Full Article

Schizophrenia-Associated HERG Channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that Is Rescued through Proteasome Inhibition for High Throughput Screening
Scientists characterized Kv11.1-3.1 cellular localization and showed decreased channel expression and cell surface trafficking relative to the Per-Ant-Sim-domain containing major isoform, Kv11.1-1A. [Sci Rep] Full Article

Differentiation of Human Gingival Mesenchymal Stem Cells into Neuronal Lineages in 3D Bioconjugated Injectable Protein Hydrogel Construct for the Management of Neuronal Disorder
Human gingival mesenchymal stem cells were, with due induction, differentiated to neuronal lineages to overcome the problems associated with birth tissue-related stem cells. [Exp Mol Med] Full Article

Therapeutic Potential of Human Olfactory Bulb Neural Stem Cells for Spinal Cord Injury in Rats
Investigators assessed the therapeutic potential of human olfactory bulb neural stem cells-GFP and their ability to survive, proliferate, differentiate and to restore lost sensory motor functions following their engraftment in spinal cord injury. [Spinal Cord] Abstract

Mechanisms and Functions of GABA Co-Release
Several populations of neurons previously thought to release only glutamate, acetylcholine, dopamine or histamine also release the major inhibitory neurotransmitter GABA. The authors review these findings and discuss the implications of GABA co-release for synaptic transmission and plasticity. [Nat Rev Neurosci] Abstract

Maladaptive Plasticity in Tinnitus – Triggers, Mechanisms and Treatment
The reviewers highlight the links between animal and human studies, and discuss several therapeutic approaches that have been developed to target the neuroplastic changes underlying tinnitus. [Nat Rev Neurol] Abstract

Energy Metabolism in Neuronal/Glial Induction and iPSC-Based Modeling of Brain Disorders
The authors address brain energy metabolism and its inter-cellular metabolic compartmentalization. They then review the findings related to the mitochondrial and metabolic reconfiguration occurring upon neuronal/glial specification from pluripotent stem cells (PSCs). [Semin Cell Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.
Scripps Florida Scientists Win $1.7 Million Grant to Advance New Strategies to Treat Huntington’s Disease
Scientists have won nearly $1.7 million from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke to investigate the mechanisms that contribute to Huntington’s disease, a fatal inherited disease that some have described as having ALS, Parkinson’s and Alzheimer’s—at the same time. [The Scripps Research Institute] Press Release

Nuviant Medical’s Neurostimulation System Selected by GlaxoSmithKline for Research in Bioelectronic Medicine
Nuviant Medical, Inc. announced that GlaxoSmithKline has selected Nuviant’s proprietary neurostimulation system as a research platform for further exploration of the clinical applications of bioelectronic medicine. [Nuviant Medical, Inc.] Press Release

Apogenix Receives €3 Million Grant for the Development of a Companion Diagnostic Test for Lead Immuno-Oncology Candidate APG101
Apogenix announced that it has received funding approval in the amount of €3 million from the German Federal Ministry of Education and Research for the so-called CancerMark project. The funds will be used for the further development of lead immuno-oncology candidate APG101 as a personalized therapy for the treatment of glioblastoma. [Apogenix] Press Release

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NEW 12th International Conference of the Asian Clinical Oncology Society (ACOS)
April 8-10, 2016
New Delhi, India

Visit our events page to see a complete list of events in the neural cell community.
NEW Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies)

NEW Postdoctoral Fellow – Gene Control of Neural Network (Baylor College of Medcine)

NEW Postdoctoral Fellowship – Adult Neurogenesis and Brain Cancer (Medical Research Council)

NEW Postdoctoral Fellowship – Neural Circuits and Behavior (Rutgers University)

NEW Postdoctoral Fellowship – Neural Stem Cell Biology (University of Tromsø)

Postdoctoral Researcher – Brain Cancer (University of Oxford)

PhD Positions – Cancer/Brain Tumor Research (Plymouth University)

Postdoctoral Fellow Positions – Neuroscience/Neuroimmunology (Stanford University)

Postdoctoral Fellow – Neuroscience (Max Planck Florida Institute for Neuroscience)

Postdoctoral Fellowship – Regulation/Function/Structure of the Synapse (National Institutes of Health)

Postdoctoral Fellowship – Cognitive Neurology (University Medical Center Gottingen)

Postdoctoral Fellowship – Neurobiology of Homeostasis (University of California San Francisco)

PhD Studentship – Clinical Vision & Neuroscience (University Medical Center Groningen)

PhD Studentship – Various Projects (Hector Fellow Academy)

Neurogenetics Research and Clinical Genetic Counselor (Howard Hughes Medical Institute)

Postdoctoral Fellow – Pediatric Brain Cancer (Fred Hutchinson Cancer Research Center)

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