Volume 10.05 | Feb 10

Neural Cell News 10.05 February 10, 2016
Neural Cell News
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TOP STORY
New Drug Target for Rett Syndrome
Researchers have identified a faulty signaling pathway that, when corrected in mice, ameliorates the symptoms of Rett syndrome, a devastating neurological condition. The findings could lead to the discovery of compounds or drugs that may benefit children affected by the disease. [Press release from Harvard University discussing online prepublication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Transplanted Neurons Integrate into Adult Retinas and Respond to Light
The authors transplanted GFP-labelled retinal ganglion cells (RGCs) into uninjured rat retinas in vivo by intravitreal injection. Transplanted RGCs acquired the general morphology of endogenous RGCs, with axons orienting towards the optic nerve head of the host retina and dendrites growing into the inner plexiform layer. [Nat Commun] Full Article

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch
Researchers showed that the histone deacetylase Hdac3 controls oligodendrocyte-specification gene Olig2 expression and functions as a molecular switch for oligodendrocyte and astrocyte lineage determination. [Dev Cell] Abstract | Graphical Abstract

Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation
Scientists aimed at marrying the power of the BXD panel, a mouse genetic reference population, with the flexibility of a cell culture model of adult neural precursor proliferation and differentiation. [Stem Cells] Abstract

MicroRNA-145 Regulates Neural Stem Cell Differentiation through the Sox2–Lin28/Let-7 Signaling Pathway
The authors investigated the precise role of microRNA (miR)-145 in neural stem cell fate decision, and the possible involvement of the Sox2–Lin28/let-7 signaling pathway in miR-145 regulatory network. [Stem Cells] Abstract

BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma
Investigators observed that BKM-120 has potent anti-invasive effects in glioblastoma cell lines and patient-derived glioma cells in vitro. [Sci Rep] Full Article

Transcriptional Comparison of Human Induced and Primary Midbrain Dopaminergic Neurons
Researchers optimized a protocol to efficiently generate induced dopaminergic (iDA) neurons from human pluripotent stem cells (hPSCs). They then sequenced the transcriptomes of iDA neurons derived from six different hPSC lines and compared them to that of primary midbrain neurons. [Sci Rep] Full Article

Transplantation of Neural Progenitor Cells in Chronic Spinal Cord Injury
Investigators tested whether transplanted neural progenitor cells can also improve functional recovery after chronic spinal cord injury alone or in combination with the reduction of glial scar and neurotrophic support. [Neuroscience] Abstract

Mifepristone-Inducible Transgene Expression in Neural Progenitor Cells In Vitro and In Vivo
Scientists described the production of a mifepristone-inducible vector system for regulated expression of transgenes within the central nervous system. The inducible system used a lentivirus-based vector platform for the ex vivo production of mifepristone-inducible murine neural progenitor cells that express transgenes of interest. [Gene Ther] Abstract

Morphine Inhibited the Rat Neural Stem Cell Proliferation Rate by Increasing Neuro Steroid Genesis
To address the potent modulatory effect of morphine on neural multipotent precursors with emphasis on endogenous sex-related neurosteroids biosynthesis, the authors primed rat neural stem cells isolated from embryonic rat telencephalon to various concentrations of morphine including 10, 20, 50 and 100 µM alone or in combination with naloxone over period of 72 hours. [Neurochem Res] Abstract

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REVIEWS
Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders
A 2012 National Institute of Mental Health workshop produced a set of recommendations to advance basic research and engage industry in cell-based studies of neuropsychiatric disorders. The author describes progress in meeting these recommendations. [Stem Cells] Abstract

Microglia: A Unique Versatile Cell in the Central Nervous System
The authors highlight the latest advance in the understanding of the nature of microglia in the central nervous system, from their origin to both the physiological and pathological roles throughout their whole life. [ACS Chem Neurosci] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.

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INDUSTRY NEWS
Dream Team Gets $11.7 Million to Fight Brain Cancers
A “Dream Team” of top Canadian scientists is launching a new attack on brain cancers. The team will receive $11.7 million over four years from Stand Up To Cancer Canada, Genome Canada, the Canadian Institutes of Health Research, the Cancer Stem Cell Consortium, and Ontario Institute for Cancer Research. [Canadian Stem Cell Foundation] Press Release

DNAtrix’s Oncolytic Immunotherapy, DNX-2401, Awarded EU Orphan Medicine Designation for Treating Malignant Brain Tumors
DNAtrix announced that its lead product, DNX-2401, has been designated by the European Commission as an orphan medicinal product for the treatment of glioma. [DNAtrix] Press Release

Amarantus Receives Orphan Drug Designation from the US FDA for Eltoprazine in the Treatment of Parkinson’s Disease Levodopa-Induced Dyskinesia
Amarantus BioScience Holdings, Inc. announced that it has received orphan drug designation from the US FDA for Eltoprazine in the treatment of Parkinson’s disease levodopa-induced dyskinesia. [Amarantus BioScience Holdings, Inc.] Press Release

$1 Million Investment to Launch Grand Challenge to Develop a TDP43 Biomarker
The ALS Association, in partnership with ALS Finding a Cure, announced a Grand Challenge to generate a biomarker to track TDP43 aggregation. The successful team(s) with the most developed plan will receive up to a $1 million investment. [The ALS Association] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW American Society of Gene & Cell Therapy (ASGCT) 19th Annual Meeting 2016
May 4-7, 2016
Washington, United States

Visit our events page to see a complete list of events in the neural cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Brain Cancer (University of Oxford)

NEW PhD Positions – Cancer/Brain Tumor Research (Plymouth University)

Postdoctoral Fellow Positions – Neuroscience/Neuroimmunology (Stanford University)

Postdoctoral Fellow – Neuroscience (Max Planck Florida Institute for Neuroscience)

Postdoctoral Fellowship – Regulation/Function/Structure of the Synapse (National Institutes of Health)

Postdoctoral Fellowship – Cognitive Neurology (University Medical Center Gottingen)

Postdoctoral Fellowship – Neurobiology of Homeostasis (University of California San Francisco)

PhD Studentship – Clinical Vision & Neuroscience (University Medical Center Groningen)

Group Leader – Neuroscience (Neuroscience in Bordeaux)

PhD Studentship – Various Projects (Hector Fellow Academy)

Neurogenetics Research and Clinical Genetic Counselor (Howard Hughes Medical Institute)

Postdoctoral Fellow – Pediatric Brain Cancer (Fred Hutchinson Cancer Research Center)


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